Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis

Benedetto Falsini, Antonio Bardocci, Silvano Cermola, Vittorio Porciatti, Giovanni Porrello

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.

Original languageEnglish (US)
Pages (from-to)325-336
Number of pages12
JournalDocumenta Ophthalmologica
Volume79
Issue number4
DOIs
StatePublished - Dec 1 1992
Externally publishedYes

Keywords

  • Optic neuritis
  • pattern electroretinogram
  • sinusoidal gratings
  • spatial frequency

ASJC Scopus subject areas

  • Ophthalmology

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