Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis

Benedetto Falsini, Antonio Bardocci, Silvano Cermola, Vittorio Porciatti, Giovanni Porrello

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.

Original languageEnglish
Pages (from-to)325-336
Number of pages12
JournalDocumenta Ophthalmologica
Volume79
Issue number4
DOIs
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Optic Neuritis
Retinal Neurons

Keywords

  • Optic neuritis
  • pattern electroretinogram
  • sinusoidal gratings
  • spatial frequency

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis. / Falsini, Benedetto; Bardocci, Antonio; Cermola, Silvano; Porciatti, Vittorio; Porrello, Giovanni.

In: Documenta Ophthalmologica, Vol. 79, No. 4, 01.12.1992, p. 325-336.

Research output: Contribution to journalArticle

Falsini, Benedetto ; Bardocci, Antonio ; Cermola, Silvano ; Porciatti, Vittorio ; Porrello, Giovanni. / Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis. In: Documenta Ophthalmologica. 1992 ; Vol. 79, No. 4. pp. 325-336.
@article{9f23e1e1100c4599b263fb78e5960199,
title = "Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis",
abstract = "Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.",
keywords = "Optic neuritis, pattern electroretinogram, sinusoidal gratings, spatial frequency",
author = "Benedetto Falsini and Antonio Bardocci and Silvano Cermola and Vittorio Porciatti and Giovanni Porrello",
year = "1992",
month = "12",
day = "1",
doi = "10.1007/BF00160947",
language = "English",
volume = "79",
pages = "325--336",
journal = "Documenta Ophthalmologica",
issn = "0012-4486",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis

AU - Falsini, Benedetto

AU - Bardocci, Antonio

AU - Cermola, Silvano

AU - Porciatti, Vittorio

AU - Porrello, Giovanni

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.

AB - Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.

KW - Optic neuritis

KW - pattern electroretinogram

KW - sinusoidal gratings

KW - spatial frequency

UR - http://www.scopus.com/inward/record.url?scp=0026633913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026633913&partnerID=8YFLogxK

U2 - 10.1007/BF00160947

DO - 10.1007/BF00160947

M3 - Article

C2 - 1633744

AN - SCOPUS:0026633913

VL - 79

SP - 325

EP - 336

JO - Documenta Ophthalmologica

JF - Documenta Ophthalmologica

SN - 0012-4486

IS - 4

ER -