Abstract
Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.
| Original language | English |
|---|---|
| Pages (from-to) | 325-336 |
| Number of pages | 12 |
| Journal | Documenta Ophthalmologica |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 1992 |
| Externally published | Yes |
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Keywords
- Optic neuritis
- pattern electroretinogram
- sinusoidal gratings
- spatial frequency
ASJC Scopus subject areas
- Ophthalmology
Cite this
Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis. / Falsini, Benedetto; Bardocci, Antonio; Cermola, Silvano; Porciatti, Vittorio; Porrello, Giovanni.
In: Documenta Ophthalmologica, Vol. 79, No. 4, 01.12.1992, p. 325-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pattern electroretinogram as a function of spatial frequency after retrobulbar optic neuritis
AU - Falsini, Benedetto
AU - Bardocci, Antonio
AU - Cermola, Silvano
AU - Porciatti, Vittorio
AU - Porrello, Giovanni
PY - 1992/12/1
Y1 - 1992/12/1
N2 - Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.
AB - Steady-state (8-Hz) pattern electroretinograms in response to counterphased sinusoidal gratings of variable spatial frequency (0.6-4.8 c/deg) were recorded in 17 patients who had had retrobulbar optic neuritis in one or both eyes (23 eyes with a clinical history of optic neuritis) and in 21 age-matched normal subjects. Amplitude and phase of the Fourier-analyzed pattern electroretinogram second harmonic were measured. The mean pattern electroretinogram amplitude of patients was significantly reduced compared with that of controls. Amplitude reductions were more marked at intermediate (1-1.4 c/deg) than at lower or higher spatial frequencies. Therefore, the average amplitude versus spatial frequency response function differed significantly in patients compared with controls, displaying a lowpass instead of a band-pass shape. No significant differences in the mean pattern electroretinogram phase were observed between groups at any spatial frequency. These results indicate spatial frequency-dependent abnormalities in the pattern electroretinogram amplitude after optic neuritis, suggesting a specific loss of retinal neurons sensitive to stimuli of intermediate spatial frequencies.
KW - Optic neuritis
KW - pattern electroretinogram
KW - sinusoidal gratings
KW - spatial frequency
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UR - http://www.scopus.com/inward/citedby.url?scp=0026633913&partnerID=8YFLogxK
U2 - 10.1007/BF00160947
DO - 10.1007/BF00160947
M3 - Article
C2 - 1633744
AN - SCOPUS:0026633913
VL - 79
SP - 325
EP - 336
JO - Documenta Ophthalmologica
JF - Documenta Ophthalmologica
SN - 0012-4486
IS - 4
ER -