Patient-reported quality of life after stereotactic body radiation therapy versus moderate hypofractionation for clinically localized prostate cancer

Skyler Bryce Johnson, Pamela R. Soulos, Timothy D. Shafman, Constantine A. Mantz, Arie P. Dosoretz, Rudi Ross, Steven E. Finkelstein, Sean P. Collins, Simeng Suy, Jeffrey V. Brower, Mark A. Ritter, Christopher R. King, Patrick A. Kupelian, Eric M. Horwitz, Alan Pollack, Matthew C. Abramowitz, Mark A. Hallman, Sergio Faria, Cary P. Gross, James B. Yu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background and purpose Evaluate changes in bowel, urinary and sexual patient-reported quality of life following treatment with moderately hypofractionated radiotherapy (<5 Gray/fraction) or stereotactic body radiation therapy (SBRT;5–10 Gray/fraction) for prostate cancer. Materials and methods In a pooled multi-institutional analysis of men treated with moderate hypofractionation or SBRT, we compared minimally detectable difference in bowel, urinary and sexual quality of life at 1 and 2 years using chi-squared analysis and logistic regression. Results 378 men received moderate hypofractionation compared to 534 men who received SBRT. After 1 year, patients receiving moderate hypofractionation were more likely to experience worsening in bowel symptoms (39.5%) compared to SBRT (32.5%; p = .06), with a larger difference at 2 years (37.4% versus 25.3%, p = .002). Similarly, patients receiving moderate fractionation had worsening urinary symptom score compared to patients who underwent SBRT at 1 and 2 years (34.7% versus 23.1%, p < .001; and 32.8% versus 14.0%, p < .001). There was no difference in sexual symptom score at 1 or 2 years. After adjusting for age and cancer characteristics, patients receiving SBRT were less likely to experience worsening urinary symptom scores at 2 years (odds ratio: 0.24[95%CI: 0.07–0.79]). Conclusions Patients who received SBRT or moderate hypofractionation have similar patient-reported change in bowel and sexual symptoms, although there was worse change in urinary symptoms for patients receiving moderate hypofractionation.

Original languageEnglish (US)
Pages (from-to)294-298
Number of pages5
JournalRadiotherapy and Oncology
Issue number2
StatePublished - Nov 1 2016


  • Hypofractionated
  • Prostate cancer
  • Quality of life
  • Radiation
  • SBRT

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging


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