Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines

Mariama El Baroudi, Dario La Sala, Caterina Cinti, Enrico Capobianco

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. Methods. Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel on a few cell lines (MCF-7 for BC and A375 for melanoma). Starting from differential expression after treatment with a demethylating agent, the 5-Aza-2'-deoxycytidine (DAC), we provided pathway enrichment analysis and gene regulatory maps with cross-linked microRNAs and transcription factors. Results: Several oncogenic signaling pathways altered upon DAC treatment were detected with significant enrichment. We represented the association between these cancers by depicting the landscape of common and specific variation affecting them.

Original languageEnglish (US)
Article numberS8
JournalTheoretical Biology and Medical Modelling
Volume11
Issue numberSUPPL.1
DOIs
StatePublished - May 7 2014

Keywords

  • Cancer
  • Demethylation
  • Pathway Landscapes
  • Regulatory Networks

ASJC Scopus subject areas

  • Modeling and Simulation
  • Health Informatics

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