Pathophysiology of the vascular wall

The role of nitric oxide in renal disease

Leopoldo Raij, E. Jaimes, D. Del Castillo, J. Guerra, G. Westberg

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Nitric oxide (NO) is formed in the endothelium by the constitutive enzyme NO synthase from the substrate amino acid L-arginine. As an endogenous vasodilator it contributes to renal arteriolar tone and modulates relaxation of the mesangium, thus contributing to regulation of glomerular microcirculation. NO also plays a role in regulating renal sodium excretion and renin release. It has antiplatelet and antithrombogenic effects and thus helps prevent thrombosis within the glomerular capillaries. In sepsis and sepsis-related syndromes, NO has a renoprotective role in that it aids in maintaining renal vasodilation and inhibiting platelet adhesion and aggregation. More knowledge of these effects may lead to the design of therapeutic interventions for preventing glomerular injury.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume54
Issue number1
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Blood Vessels
Nitric Oxide
Kidney
Microcirculation
Systemic Inflammatory Response Syndrome
Platelets
Vasodilator Agents
Platelet Aggregation
Renin
Vasodilation
Nitric Oxide Synthase
Endothelium
Arginine
Sepsis
Thrombosis
Adhesion
Agglomeration
Sodium
Amino Acids
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Pathophysiology of the vascular wall : The role of nitric oxide in renal disease. / Raij, Leopoldo; Jaimes, E.; Del Castillo, D.; Guerra, J.; Westberg, G.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 54, No. 1, 01.01.1996, p. 53-58.

Research output: Contribution to journalArticle

Raij, Leopoldo ; Jaimes, E. ; Del Castillo, D. ; Guerra, J. ; Westberg, G. / Pathophysiology of the vascular wall : The role of nitric oxide in renal disease. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 1996 ; Vol. 54, No. 1. pp. 53-58.
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