Abstract
Atherosclerosis and plaque rupture represent complex "traits" of unknown cause that involve multiple genes and their variants. Novel genomic technologies provide us with the tools that will allow for the identification of groupings of genes that determine either susceptibility or resistance relative to the development of atherosclerosis and its thromboembolic complications. This information may, in turn, lead to a clearer understanding of the cause and risk for atherosclerosis. Diagnostic tools, as well as preventive and therapeutic strategies, will be derived from such heightened understanding of the disease process. With this chapter, we have presented the current state of knowledge of atherosclerosis genomics.
| Original language | English |
|---|---|
| Pages (from-to) | 323-338 |
| Number of pages | 16 |
| Journal | Progress in Cardiovascular Diseases |
| Volume | 44 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 30 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Pathophysiology of plaque instability : Insights at the genomic level. / Lopes, Neuza; Vasudevan, Sanjay S.; Alvarez, Rene J.; Binkley, Philip F.; Goldschmidt-Clermont, Pascal.
In: Progress in Cardiovascular Diseases, Vol. 44, No. 5, 30.05.2002, p. 323-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of plaque instability
T2 - Insights at the genomic level
AU - Lopes, Neuza
AU - Vasudevan, Sanjay S.
AU - Alvarez, Rene J.
AU - Binkley, Philip F.
AU - Goldschmidt-Clermont, Pascal
PY - 2002/5/30
Y1 - 2002/5/30
N2 - Atherosclerosis and plaque rupture represent complex "traits" of unknown cause that involve multiple genes and their variants. Novel genomic technologies provide us with the tools that will allow for the identification of groupings of genes that determine either susceptibility or resistance relative to the development of atherosclerosis and its thromboembolic complications. This information may, in turn, lead to a clearer understanding of the cause and risk for atherosclerosis. Diagnostic tools, as well as preventive and therapeutic strategies, will be derived from such heightened understanding of the disease process. With this chapter, we have presented the current state of knowledge of atherosclerosis genomics.
AB - Atherosclerosis and plaque rupture represent complex "traits" of unknown cause that involve multiple genes and their variants. Novel genomic technologies provide us with the tools that will allow for the identification of groupings of genes that determine either susceptibility or resistance relative to the development of atherosclerosis and its thromboembolic complications. This information may, in turn, lead to a clearer understanding of the cause and risk for atherosclerosis. Diagnostic tools, as well as preventive and therapeutic strategies, will be derived from such heightened understanding of the disease process. With this chapter, we have presented the current state of knowledge of atherosclerosis genomics.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036098205&partnerID=8YFLogxK
U2 - 10.1053/pcad.2002.125097
DO - 10.1053/pcad.2002.125097
M3 - Article
C2 - 12024331
AN - SCOPUS:0036098205
VL - 44
SP - 323
EP - 338
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
SN - 0033-0620
IS - 5
ER -