Pathophysiology of plaque instability: Insights at the genomic level

Neuza Lopes, Sanjay S. Vasudevan, Rene J. Alvarez, Philip F. Binkley, Pascal Goldschmidt-Clermont

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Atherosclerosis and plaque rupture represent complex "traits" of unknown cause that involve multiple genes and their variants. Novel genomic technologies provide us with the tools that will allow for the identification of groupings of genes that determine either susceptibility or resistance relative to the development of atherosclerosis and its thromboembolic complications. This information may, in turn, lead to a clearer understanding of the cause and risk for atherosclerosis. Diagnostic tools, as well as preventive and therapeutic strategies, will be derived from such heightened understanding of the disease process. With this chapter, we have presented the current state of knowledge of atherosclerosis genomics.

Original languageEnglish
Pages (from-to)323-338
Number of pages16
JournalProgress in Cardiovascular Diseases
Volume44
Issue number5
DOIs
StatePublished - May 30 2002
Externally publishedYes

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Atherosclerosis
Genomics
Genes
Rupture
Technology
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lopes, N., Vasudevan, S. S., Alvarez, R. J., Binkley, P. F., & Goldschmidt-Clermont, P. (2002). Pathophysiology of plaque instability: Insights at the genomic level. Progress in Cardiovascular Diseases, 44(5), 323-338. https://doi.org/10.1053/pcad.2002.125097

Pathophysiology of plaque instability : Insights at the genomic level. / Lopes, Neuza; Vasudevan, Sanjay S.; Alvarez, Rene J.; Binkley, Philip F.; Goldschmidt-Clermont, Pascal.

In: Progress in Cardiovascular Diseases, Vol. 44, No. 5, 30.05.2002, p. 323-338.

Research output: Contribution to journalArticle

Lopes, N, Vasudevan, SS, Alvarez, RJ, Binkley, PF & Goldschmidt-Clermont, P 2002, 'Pathophysiology of plaque instability: Insights at the genomic level', Progress in Cardiovascular Diseases, vol. 44, no. 5, pp. 323-338. https://doi.org/10.1053/pcad.2002.125097
Lopes N, Vasudevan SS, Alvarez RJ, Binkley PF, Goldschmidt-Clermont P. Pathophysiology of plaque instability: Insights at the genomic level. Progress in Cardiovascular Diseases. 2002 May 30;44(5):323-338. https://doi.org/10.1053/pcad.2002.125097
Lopes, Neuza ; Vasudevan, Sanjay S. ; Alvarez, Rene J. ; Binkley, Philip F. ; Goldschmidt-Clermont, Pascal. / Pathophysiology of plaque instability : Insights at the genomic level. In: Progress in Cardiovascular Diseases. 2002 ; Vol. 44, No. 5. pp. 323-338.
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