Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: Implications for screening and prevention

M. Jacob Adams, Steven E Lipshultz

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Great progress has been made in treating childhood cancers over the past 40 years. Along with second malignancies, a major complication of anti-cancer therapies is adverse cardiovascular effects, especially cardiomyopathy and coronary artery disease. The pathophysiology and characteristics of cardiomyopathy associated with radiation therapy and anthracycline therapy are distinctive. We describe each type of cardiomyopathy, along with its risk factors. These distinctive cardiomyopathies require different screening tests. Appropriate screening of the entire cardiovascular system should be performed because radiation and chemotherapy affect the entire system. Prevention recommendations focus on cardiomyopathy and coronary artery disease.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalPediatric Blood and Cancer
Volume44
Issue number7
DOIs
StatePublished - Jun 15 2005

Fingerprint

Anthracyclines
Cardiomyopathies
Radiation
Coronary Artery Disease
Second Primary Neoplasms
Cardiovascular System
Neoplasms
Radiotherapy
Drug Therapy
Therapeutics

Keywords

  • Anthracyclines
  • Cardiomyopathy
  • Coronary artery disease
  • Lymphomas and pediatric oncology
  • Radiation effects

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Pathophysiology of anthracycline- and radiation-associated cardiomyopathies : Implications for screening and prevention. / Adams, M. Jacob; Lipshultz, Steven E.

In: Pediatric Blood and Cancer, Vol. 44, No. 7, 15.06.2005, p. 600-606.

Research output: Contribution to journalArticle

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