Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: Implications for screening and prevention

M. Jacob Adams, Steven E. Lipshultz

Research output: Contribution to journalArticle

165 Scopus citations

Abstract

Great progress has been made in treating childhood cancers over the past 40 years. Along with second malignancies, a major complication of anti-cancer therapies is adverse cardiovascular effects, especially cardiomyopathy and coronary artery disease. The pathophysiology and characteristics of cardiomyopathy associated with radiation therapy and anthracycline therapy are distinctive. We describe each type of cardiomyopathy, along with its risk factors. These distinctive cardiomyopathies require different screening tests. Appropriate screening of the entire cardiovascular system should be performed because radiation and chemotherapy affect the entire system. Prevention recommendations focus on cardiomyopathy and coronary artery disease.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalPediatric Blood and Cancer
Volume44
Issue number7
DOIs
StatePublished - Jun 15 2005
Externally publishedYes

Keywords

  • Anthracyclines
  • Cardiomyopathy
  • Coronary artery disease
  • Lymphomas and pediatric oncology
  • Radiation effects

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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