Pathophysiology of acute wound healing

Research output: Contribution to journalArticle

571 Scopus citations

Abstract

Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalClinics in Dermatology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Dermatology

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