Abstract
Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 9-18 |
| Number of pages | 10 |
| Journal | Clinics in Dermatology |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2007 |
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ASJC Scopus subject areas
- Dermatology
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Pathophysiology of acute wound healing. / Li, Jie; Chen, Juan; Kirsner, Robert.
In: Clinics in Dermatology, Vol. 25, No. 1, 01.01.2007, p. 9-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of acute wound healing
AU - Li, Jie
AU - Chen, Juan
AU - Kirsner, Robert
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.
AB - Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.
UR - http://www.scopus.com/inward/record.url?scp=33846627240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846627240&partnerID=8YFLogxK
U2 - 10.1016/j.clindermatol.2006.09.007
DO - 10.1016/j.clindermatol.2006.09.007
M3 - Article
C2 - 17276196
AN - SCOPUS:33846627240
VL - 25
SP - 9
EP - 18
JO - Clinics in Dermatology
JF - Clinics in Dermatology
SN - 0738-081X
IS - 1
ER -