Pathophysiological alterations in the central nervous system due to trauma

R. Bullock

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Neurotrauma is the largest cause of death and severe disability in young adults. In this review, the pathophysiological processes which damage the brain and spinal cord, both acutely, and hours to days after injury, are discussed. Secondary, delayed damage is the major cause of bad outcome in at least 40% of patients, with severe head injury. Diffuse damage to axons, hypoxic-ischaemic damage to neurons and astrocytes, contusions, intracranial haematomas, and brain swelling are discussed. The prospect for improving outcome by pharmacological therapy, and the current status of head injury trials are presented.

Original languageEnglish (US)
Pages (from-to)449-458
Number of pages10
JournalSchweizerische Medizinische Wochenschrift
Issue number11
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Pathophysiological alterations in the central nervous system due to trauma'. Together they form a unique fingerprint.

Cite this