Pathophysiological alterations in the central nervous system due to trauma

Ross Bullock

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neurotrauma is the largest cause of death and severe disability in young adults. In this review, the pathophysiological processes which damage the brain and spinal cord, both acutely, and hours to days after injury, are discussed. Secondary, delayed damage is the major cause of bad outcome in at least 40% of patients, with severe head injury. Diffuse damage to axons, hypoxic-ischaemic damage to neurons and astrocytes, contusions, intracranial haematomas, and brain swelling are discussed. The prospect for improving outcome by pharmacological therapy, and the current status of head injury trials are presented.

Original languageEnglish
Pages (from-to)449-458
Number of pages10
JournalSchweizerische Medizinische Wochenschrift
Volume123
Issue number11
StatePublished - Jan 1 1993
Externally publishedYes

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Craniocerebral Trauma
Central Nervous System
Contusions
Brain Edema
Wounds and Injuries
Astrocytes
Hematoma
Axons
Young Adult
Cause of Death
Spinal Cord
Pharmacology
Neurons
Brain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pathophysiological alterations in the central nervous system due to trauma. / Bullock, Ross.

In: Schweizerische Medizinische Wochenschrift, Vol. 123, No. 11, 01.01.1993, p. 449-458.

Research output: Contribution to journalArticle

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