Abstract
The skull is an uncommon location for primary bone tumors. Those that arise in this location are often malignant, and the most common are chordoma and chondrosarcoma. These tumors have some overlapping clinicopathological features but can be distinguished by their morphology and immunohistochemical profile. Histologically chordoma demonstrates lobules of cohesive polyhedral cells with vacuolated cytoplasm in a mucinous or myxoid matrix; immunohistochemistry for brachyury is positive. Chondrosarcoma shows chondrocytes with increased cellularity and atypia in a hyaline or myxoid cartilaginous matrix; immunohistochemistry for brachyury is negative. Chordoma is the most common primary sarcoma of the axial skeleton and arises with approximately equal frequently in the skull base, mobile spine, and sacrococcygeal region. The spine is a more common site than the skull base for chondrosarcoma. Chordoma and chondrosarcoma are usually treated by a combining surgical resection and radiation therapy. Overall, chondrosarcoma has a better prognosis than chordoma.
| Original language | English (US) |
|---|---|
| Title of host publication | Chordomas and Chondrosarcomas of the Skull Base and Spine |
| Publisher | Elsevier Inc. |
| Pages | 11-21 |
| Number of pages | 11 |
| ISBN (Electronic) | 9780128043332 |
| ISBN (Print) | 9780128042571 |
| DOIs | |
| State | Published - Sep 18 2017 |
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Keywords
- Chondrosarcoma
- Chordoma
- Neoplasm
- Sarcoma
- Skull base
- Spine
ASJC Scopus subject areas
- Medicine(all)
- Neuroscience(all)
Cite this
Pathology of chordoma and chondrosarcoma of the axial skeleton. / Kerr, Darcy; Rosenberg, Andrew.
Chordomas and Chondrosarcomas of the Skull Base and Spine. Elsevier Inc., 2017. p. 11-21.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Pathology of chordoma and chondrosarcoma of the axial skeleton
AU - Kerr, Darcy
AU - Rosenberg, Andrew
PY - 2017/9/18
Y1 - 2017/9/18
N2 - The skull is an uncommon location for primary bone tumors. Those that arise in this location are often malignant, and the most common are chordoma and chondrosarcoma. These tumors have some overlapping clinicopathological features but can be distinguished by their morphology and immunohistochemical profile. Histologically chordoma demonstrates lobules of cohesive polyhedral cells with vacuolated cytoplasm in a mucinous or myxoid matrix; immunohistochemistry for brachyury is positive. Chondrosarcoma shows chondrocytes with increased cellularity and atypia in a hyaline or myxoid cartilaginous matrix; immunohistochemistry for brachyury is negative. Chordoma is the most common primary sarcoma of the axial skeleton and arises with approximately equal frequently in the skull base, mobile spine, and sacrococcygeal region. The spine is a more common site than the skull base for chondrosarcoma. Chordoma and chondrosarcoma are usually treated by a combining surgical resection and radiation therapy. Overall, chondrosarcoma has a better prognosis than chordoma.
AB - The skull is an uncommon location for primary bone tumors. Those that arise in this location are often malignant, and the most common are chordoma and chondrosarcoma. These tumors have some overlapping clinicopathological features but can be distinguished by their morphology and immunohistochemical profile. Histologically chordoma demonstrates lobules of cohesive polyhedral cells with vacuolated cytoplasm in a mucinous or myxoid matrix; immunohistochemistry for brachyury is positive. Chondrosarcoma shows chondrocytes with increased cellularity and atypia in a hyaline or myxoid cartilaginous matrix; immunohistochemistry for brachyury is negative. Chordoma is the most common primary sarcoma of the axial skeleton and arises with approximately equal frequently in the skull base, mobile spine, and sacrococcygeal region. The spine is a more common site than the skull base for chondrosarcoma. Chordoma and chondrosarcoma are usually treated by a combining surgical resection and radiation therapy. Overall, chondrosarcoma has a better prognosis than chordoma.
KW - Chondrosarcoma
KW - Chordoma
KW - Neoplasm
KW - Sarcoma
KW - Skull base
KW - Spine
UR - http://www.scopus.com/inward/record.url?scp=85054306076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054306076&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-804257-1.00002-5
DO - 10.1016/B978-0-12-804257-1.00002-5
M3 - Chapter
SN - 9780128042571
SP - 11
EP - 21
BT - Chordomas and Chondrosarcomas of the Skull Base and Spine
PB - Elsevier Inc.
ER -