Pathology of chordoma and chondrosarcoma of the axial skeleton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The skull is an uncommon location for primary bone tumors. Those that arise in this location are often malignant, and the most common are chordoma and chondrosarcoma. These tumors have some overlapping clinicopathological features but can be distinguished by their morphology and immunohistochemical profile. Histologically chordoma demonstrates lobules of cohesive polyhedral cells with vacuolated cytoplasm in a mucinous or myxoid matrix; immunohistochemistry for brachyury is positive. Chondrosarcoma shows chondrocytes with increased cellularity and atypia in a hyaline or myxoid cartilaginous matrix; immunohistochemistry for brachyury is negative. Chordoma is the most common primary sarcoma of the axial skeleton and arises with approximately equal frequently in the skull base, mobile spine, and sacrococcygeal region. The spine is a more common site than the skull base for chondrosarcoma. Chordoma and chondrosarcoma are usually treated by a combining surgical resection and radiation therapy. Overall, chondrosarcoma has a better prognosis than chordoma.

Original languageEnglish (US)
Title of host publicationChordomas and Chondrosarcomas of the Skull Base and Spine
PublisherElsevier Inc.
Pages11-21
Number of pages11
ISBN (Electronic)9780128043332
ISBN (Print)9780128042571
DOIs
StatePublished - Sep 18 2017

Fingerprint

Chordoma
Chondrosarcoma
Skeleton
Pathology
Skull Base
Spine
Immunohistochemistry
Sacrococcygeal Region
Hyalin
Chondrocytes
Skull
Sarcoma
Neoplasms
Cytoplasm
Radiotherapy
Bone and Bones

Keywords

  • Chondrosarcoma
  • Chordoma
  • Neoplasm
  • Sarcoma
  • Skull base
  • Spine

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Kerr, D., & Rosenberg, A. (2017). Pathology of chordoma and chondrosarcoma of the axial skeleton. In Chordomas and Chondrosarcomas of the Skull Base and Spine (pp. 11-21). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804257-1.00002-5

Pathology of chordoma and chondrosarcoma of the axial skeleton. / Kerr, Darcy; Rosenberg, Andrew.

Chordomas and Chondrosarcomas of the Skull Base and Spine. Elsevier Inc., 2017. p. 11-21.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kerr, D & Rosenberg, A 2017, Pathology of chordoma and chondrosarcoma of the axial skeleton. in Chordomas and Chondrosarcomas of the Skull Base and Spine. Elsevier Inc., pp. 11-21. https://doi.org/10.1016/B978-0-12-804257-1.00002-5
Kerr D, Rosenberg A. Pathology of chordoma and chondrosarcoma of the axial skeleton. In Chordomas and Chondrosarcomas of the Skull Base and Spine. Elsevier Inc. 2017. p. 11-21 https://doi.org/10.1016/B978-0-12-804257-1.00002-5
Kerr, Darcy ; Rosenberg, Andrew. / Pathology of chordoma and chondrosarcoma of the axial skeleton. Chordomas and Chondrosarcomas of the Skull Base and Spine. Elsevier Inc., 2017. pp. 11-21
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