PURPOSE OF REVIEW: The prognosis of patients with high-risk bladder cancer is generally poor. In addition to advanced stage and high-grade tumors, several histopathological subtypes of invasive bladder cancer have been identified as being more aggressive than conventional forms. However, modalities for early detection of such aggressive neoplasms are limited. This review examines the pathological features of aggressive bladder cancer and critically reviews the performance of selected methodologies that are commonly used to detect such lesions. RECENT FINDINGS: Strategies including bladder tumor antigen assay, NMP22, ImmunoCyt, and UroVysion hold promise for the early detection of aggressive urothelial carcinomas of the bladder. However, such approaches are currently limited by their sensitivity and potential for false-positive results, and are unlikely to substitute cystoscopy. SUMMARY: Molecular-based detection techniques represent potentially attractive strategies for noninvasive detection of aggressive bladder cancer using urine as the specimen source. Identification of new markers and development of novel platforms may improve detection in the future.
ASJC Scopus subject areas
Research output: Contribution to journal › Article
TY - JOUR
T1 - Pathological possibilities and pitfalls in detecting aggressive bladder cancer
AU - Mitra, Anirban P.
AU - Jorda, Merce
AU - Cote, Richard J
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Lippincott Williams & Wilkins.
AB - Lippincott Williams & Wilkins.
UR - http://www.scopus.com/inward/record.url?scp=84864856435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864856435&partnerID=8YFLogxK
U2 - 10.1097/MOU.0b013e328356ade6
DO - 10.1097/MOU.0b013e328356ade6
M3 - Article
C2 - 22825461
AN - SCOPUS:84864856435
VL - 22
SP - 397
EP - 404
JO - Current Opinion in Urology
JF - Current Opinion in Urology
SN - 0963-0643
IS - 5