Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B

Jay H. Lefkowitch, Eugene R Schiff, Gary L. Davis, Robert P. Perrillo, Karen Lindsay, Henry C. Bodenheimer, Luis A. Balart, Terryl J. Ortego, John Payne, Jules L. Dienstag, Alexandra Gibas, Ira M. Jacobson, Carlo H. Tamburro, William Carey, Christopher B O'Brien, Richard Sampliner, David H. Van Thiel, David Feit, Janice Albrecht, Carlton MeschievitzBharati Sanghvi, Roger D. Vaughan

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Abstract

Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.

Original languageEnglish
Pages (from-to)595-603
Number of pages9
JournalGastroenterology
Volume104
Issue number2
StatePublished - Dec 1 1993

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Chronic Hepatitis B
Chronic Hepatitis C
Hepacivirus
Multicenter Studies
Virus Diseases
Mallory Bodies
Odds Ratio
Hepatitis B virus
Biopsy
Liver
Fats
Bites and Stings
Bile Ducts
Interferon-alpha
Liver Diseases
Hepatocytes
Logistic Models
Confidence Intervals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lefkowitch, J. H., Schiff, E. R., Davis, G. L., Perrillo, R. P., Lindsay, K., Bodenheimer, H. C., ... Vaughan, R. D. (1993). Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B. Gastroenterology, 104(2), 595-603.

Pathological diagnosis of chronic hepatitis C : A multicenter comparative study with chronic hepatitis B. / Lefkowitch, Jay H.; Schiff, Eugene R; Davis, Gary L.; Perrillo, Robert P.; Lindsay, Karen; Bodenheimer, Henry C.; Balart, Luis A.; Ortego, Terryl J.; Payne, John; Dienstag, Jules L.; Gibas, Alexandra; Jacobson, Ira M.; Tamburro, Carlo H.; Carey, William; O'Brien, Christopher B; Sampliner, Richard; Van Thiel, David H.; Feit, David; Albrecht, Janice; Meschievitz, Carlton; Sanghvi, Bharati; Vaughan, Roger D.

In: Gastroenterology, Vol. 104, No. 2, 01.12.1993, p. 595-603.

Research output: Contribution to journalArticle

Lefkowitch, JH, Schiff, ER, Davis, GL, Perrillo, RP, Lindsay, K, Bodenheimer, HC, Balart, LA, Ortego, TJ, Payne, J, Dienstag, JL, Gibas, A, Jacobson, IM, Tamburro, CH, Carey, W, O'Brien, CB, Sampliner, R, Van Thiel, DH, Feit, D, Albrecht, J, Meschievitz, C, Sanghvi, B & Vaughan, RD 1993, 'Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B', Gastroenterology, vol. 104, no. 2, pp. 595-603.
Lefkowitch JH, Schiff ER, Davis GL, Perrillo RP, Lindsay K, Bodenheimer HC et al. Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B. Gastroenterology. 1993 Dec 1;104(2):595-603.
Lefkowitch, Jay H. ; Schiff, Eugene R ; Davis, Gary L. ; Perrillo, Robert P. ; Lindsay, Karen ; Bodenheimer, Henry C. ; Balart, Luis A. ; Ortego, Terryl J. ; Payne, John ; Dienstag, Jules L. ; Gibas, Alexandra ; Jacobson, Ira M. ; Tamburro, Carlo H. ; Carey, William ; O'Brien, Christopher B ; Sampliner, Richard ; Van Thiel, David H. ; Feit, David ; Albrecht, Janice ; Meschievitz, Carlton ; Sanghvi, Bharati ; Vaughan, Roger D. / Pathological diagnosis of chronic hepatitis C : A multicenter comparative study with chronic hepatitis B. In: Gastroenterology. 1993 ; Vol. 104, No. 2. pp. 595-603.
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abstract = "Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95{\%} confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95{\%} Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95{\%} Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95{\%} Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.",
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T1 - Pathological diagnosis of chronic hepatitis C

T2 - A multicenter comparative study with chronic hepatitis B

AU - Lefkowitch, Jay H.

AU - Schiff, Eugene R

AU - Davis, Gary L.

AU - Perrillo, Robert P.

AU - Lindsay, Karen

AU - Bodenheimer, Henry C.

AU - Balart, Luis A.

AU - Ortego, Terryl J.

AU - Payne, John

AU - Dienstag, Jules L.

AU - Gibas, Alexandra

AU - Jacobson, Ira M.

AU - Tamburro, Carlo H.

AU - Carey, William

AU - O'Brien, Christopher B

AU - Sampliner, Richard

AU - Van Thiel, David H.

AU - Feit, David

AU - Albrecht, Janice

AU - Meschievitz, Carlton

AU - Sanghvi, Bharati

AU - Vaughan, Roger D.

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N2 - Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.

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