Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B

Jay H. Lefkowitch, Eugene R. Schiff, Gary L. Davis, Robert P. Perrillo, Karen Lindsay, Henry C. Bodenheimer, Luis A. Balart, Terryl J. Ortego, John Payne, Jules L. Dienstag, Alexandra Gibas, Ira M. Jacobson, Carlo H. Tamburro, William Carey, Christopher O'Brien, Richard Sampliner, David H. Van Thiel, David Feit, Janice Albrecht, Carlton MeschievitzBharati Sanghvi, Roger D. Vaughan

Research output: Contribution to journalArticlepeer-review

355 Scopus citations


Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
Issue number2
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B'. Together they form a unique fingerprint.

Cite this