Abstract
Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.
| Original language | English |
|---|---|
| Pages (from-to) | 595-603 |
| Number of pages | 9 |
| Journal | Gastroenterology |
| Volume | 104 |
| Issue number | 2 |
| State | Published - Dec 1 1993 |
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ASJC Scopus subject areas
- Gastroenterology
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Pathological diagnosis of chronic hepatitis C : A multicenter comparative study with chronic hepatitis B. / Lefkowitch, Jay H.; Schiff, Eugene R; Davis, Gary L.; Perrillo, Robert P.; Lindsay, Karen; Bodenheimer, Henry C.; Balart, Luis A.; Ortego, Terryl J.; Payne, John; Dienstag, Jules L.; Gibas, Alexandra; Jacobson, Ira M.; Tamburro, Carlo H.; Carey, William; O'Brien, Christopher B; Sampliner, Richard; Van Thiel, David H.; Feit, David; Albrecht, Janice; Meschievitz, Carlton; Sanghvi, Bharati; Vaughan, Roger D.
In: Gastroenterology, Vol. 104, No. 2, 01.12.1993, p. 595-603.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathological diagnosis of chronic hepatitis C
T2 - A multicenter comparative study with chronic hepatitis B
AU - Lefkowitch, Jay H.
AU - Schiff, Eugene R
AU - Davis, Gary L.
AU - Perrillo, Robert P.
AU - Lindsay, Karen
AU - Bodenheimer, Henry C.
AU - Balart, Luis A.
AU - Ortego, Terryl J.
AU - Payne, John
AU - Dienstag, Jules L.
AU - Gibas, Alexandra
AU - Jacobson, Ira M.
AU - Tamburro, Carlo H.
AU - Carey, William
AU - O'Brien, Christopher B
AU - Sampliner, Richard
AU - Van Thiel, David H.
AU - Feit, David
AU - Albrecht, Janice
AU - Meschievitz, Carlton
AU - Sanghvi, Bharati
AU - Vaughan, Roger D.
PY - 1993/12/1
Y1 - 1993/12/1
N2 - Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.
AB - Background: Hepatic histological responses described in hepatitis C virus (HCV) infection include bite duct damage, lymphoid follicles and/or aggregates in portal tracts, large- and small-droplet fat, Mallory body-like material in hepatocytes, liver cell dysplasia and multinucleation, and activation of sinusoidal inflammatory cells. The specificity of these lesions for HCV infection is uncertain. Methods: In two multicenter trials of recombinant Interferon alfa therapy for chronic hepatitis C and B, the frequency of these eight lesions in pretherapy and posttherapy liver biopsy specimens was examined to determine the set of features, if any, that distinguishes HCV from hepatitis B virus (HBV) infection. The lesions were scored in 317 HCV biopsy specimens and 299 HBV specimens. Results: Stepwise logistic regression determined a set of three features more likely to be seen In HCV than in HBV infection: bile duct damage [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.8-12.3], lymphoid follicles and/or aggregates (OR, 2.4; 95% Cl, 1.2-4.7), and large-droplet fat (OR, 2.4; 95% Cl, 1.4-4.1). A fourth lesion, Mallory body-like material, was seen only in HCV biopsy specimens (OR, 71.6; 95% Cl, 4.4-996.1). Conclusions: These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027386603&partnerID=8YFLogxK
M3 - Article
C2 - 8425703
AN - SCOPUS:0027386603
VL - 104
SP - 595
EP - 603
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 2
ER -