Abstract
In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed intravascular injections of Clostridium to induce oncolysis in patients with glioblastoma. Since then, suggestions between improved survival and infectious processes have been reported in several patients with glioma, which ultimately marshaled the infamous use of intracerebral Enterobacter. These early observations of tumor regression and concomitant infection piloted a burgeoning field focusing on the use of pathogens in molecular oncology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1139-1146 |
| Number of pages | 8 |
| Journal | Journal of Neurosurgery |
| Volume | 128 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- Cancer
- Glioma
- History
- Oncology
- Pathogens
- Virus
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Pathogens and glioma : A history of unexpected discoveries ushering in novel therapy. / Shah, Ashish H.; Jusué-Torres, Ignacio; Ivan, Michael E.; Komotar, Ricardo J; Kasahara, Noriyuki.
In: Journal of Neurosurgery, Vol. 128, No. 4, 01.04.2018, p. 1139-1146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogens and glioma
T2 - A history of unexpected discoveries ushering in novel therapy
AU - Shah, Ashish H.
AU - Jusué-Torres, Ignacio
AU - Ivan, Michael E.
AU - Komotar, Ricardo J
AU - Kasahara, Noriyuki
PY - 2018/4/1
Y1 - 2018/4/1
N2 - In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed intravascular injections of Clostridium to induce oncolysis in patients with glioblastoma. Since then, suggestions between improved survival and infectious processes have been reported in several patients with glioma, which ultimately marshaled the infamous use of intracerebral Enterobacter. These early observations of tumor regression and concomitant infection piloted a burgeoning field focusing on the use of pathogens in molecular oncology.
AB - In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed intravascular injections of Clostridium to induce oncolysis in patients with glioblastoma. Since then, suggestions between improved survival and infectious processes have been reported in several patients with glioma, which ultimately marshaled the infamous use of intracerebral Enterobacter. These early observations of tumor regression and concomitant infection piloted a burgeoning field focusing on the use of pathogens in molecular oncology.
KW - Cancer
KW - Glioma
KW - History
KW - Oncology
KW - Pathogens
KW - Virus
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UR - http://www.scopus.com/inward/citedby.url?scp=85047733940&partnerID=8YFLogxK
U2 - 10.3171/2016.12.JNS162123
DO - 10.3171/2016.12.JNS162123
M3 - Article
C2 - 28598280
AN - SCOPUS:85047733940
VL - 128
SP - 1139
EP - 1146
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 4
ER -