Pathogenesis of obstructive sleep apnea

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The cycle of events detailed in Figure 323 illustrates the potential relationship between behavioral state and the collapsible human upper airway. The currently available data support the notion that the periodic airway occlusion occurring in the sleep of patients with OSA can be explained by alterations in upper airway anatomy that facilitate upper airway occlusion during sleep and that perturbations of upper airway neuromuscular control may participate in sleep-mediated closure of the upper airway. The combined effect of abnormal structure and function in the upper airway of subjects with OSA serves to alter the balance of forces affecting the compliant upper airway, such that collapsing forces exceed distending forces.

Original languageEnglish (US)
Pages (from-to)265-276
Number of pages12
JournalRespiratory care
Issue number4
StatePublished - Apr 1998

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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