Pathogenesis of HIV-associated cardiomyopathy

Giuseppe Barbaro, Steven E. Lipshultz

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Reviews and studies published before the introduction of highly active antiretroviral therapy (HAART) regimens have tracked the incidence and course of human immunodeficiency virus (HIV) infection in relation to cardiac illness in both children and adults. HAART regimens have significantly modified the course of HIV disease, with longer survival rates and improvement of life quality in HIV+ subjects expected. However, early data raised concerns about HAART's being associated with an increase in both peripheral and coronary arterial diseases. A variety of potential etiologies have been postulated in HIV-related heart disease, including myocardial infection with HIV itself, opportunistic infections, viral infections, autoimmune response to viral infection, drug-related cardiotoxicity, nutritional deficiencies, and prolonged immunosuppression. In this review article we discuss HIV-associated cardiovascular complications, focusing on pathogenetic mechanisms that may play a role in diagnosis, management, and therapy of these complications.

Original languageEnglish (US)
Pages (from-to)57-81
Number of pages25
JournalAnnals of the New York Academy of Sciences
Volume946
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Adenovirus
  • Autoimmunity
  • Chemokines
  • Coxsackievirus
  • Cytokines
  • Cytomegalovirus
  • Drug cardiotoxicity
  • Epstein-Barr virus
  • HIV
  • HIV-associated cardiomyopathy
  • HIV-associated pulmonary hypertension
  • Immunopathogenesis
  • Myocarditis
  • Nutritional disorders
  • Pathogenesis
  • Risk groups
  • Viral myocardial infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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