Pathogenesis of aging and age-related comorbidities in people with HIV: Highlights from the HIV action workshop

Dana Gabuzda, Beth D. Jamieson, Ronald G. Collman, Michael M. Lederman, Tricia H. Burdo, Steven G. Deeks, Dirk P. Dittmer, Howard S. Fox, Nicholas T. Funderburg, Savita G. Pahwa, Ivona Pandrea, Cara C. Wilson, Peter W. Hunt

Research output: Contribution to journalArticle

Abstract

People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff orga-nized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.

Original languageEnglish (US)
Pages (from-to)143-174
Number of pages32
JournalPathogens and Immunity
Volume5
Issue number1
DOIs
StatePublished - 2020

Keywords

  • Aging
  • Cellular senescence
  • HIV
  • Inflammaging
  • Microbiome

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Molecular Biology

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  • Cite this

    Gabuzda, D., Jamieson, B. D., Collman, R. G., Lederman, M. M., Burdo, T. H., Deeks, S. G., Dittmer, D. P., Fox, H. S., Funderburg, N. T., Pahwa, S. G., Pandrea, I., Wilson, C. C., & Hunt, P. W. (2020). Pathogenesis of aging and age-related comorbidities in people with HIV: Highlights from the HIV action workshop. Pathogens and Immunity, 5(1), 143-174. https://doi.org/10.20411/pai.v5i1.365