Paternal X could relate to arithmetic function; study of cognitive function and parental origin of X chromosome in Turner syndrome

Ayça T. Ergür, Gönül Öcal, Merih Berberoglu, Mustafa Tekin, Birim G. Kiliç, Zehra Aycan, Alev Kutlu, Pelin Adiyaman, Zeynep Siklar, Nejat Akar, Aynur Sahin, Duygu Akçayöz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: 45,X Turner syndrome (TS) female subjects have visuospatial skill and social cognition deficits that may arise from X-linked imprinting. The aim of the present study was to compare phenotypic characteristics and neurocognitive pattern of 12 monosomic TS girls, according to X-linked imprinting. Methods: Microsatellite markers were used to determine the parental origin of the missing chromosome X. Wechsler Intelligence Scale for Children-Revised (WISC-R) was administered as measures of general intellectual functioning. The results were compared in TS patients with maternally derived X chromosome (Xm) and paternally derived X chromosome (Xp). Results: Six out of 12 patients (50%) had Xm, and the other six (50%) had Xp chromosome. There was no difference in the total, verbal and performance IQ score between the TS subgroups with Xm and Xp. When the WISC-R subtest score patterns were compared, the mean arithmetic scores were significantly poorer in the Xm TS than in the Xp TS. Conclusion: In monosomic TS cases, paternal imprinting may predict arithmetic ability, on the other hand, reductionist consideration defined by genetic imprinting is not sufficient to confirm this. Further studies should be undertaken to clarify this situation.

Original languageEnglish (US)
Pages (from-to)172-174
Number of pages3
JournalPediatrics International
Volume50
Issue number2
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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Keywords

  • Cognitive functions
  • Maternal imprinting X
  • Paternal imprinting X
  • X-monosomy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ergür, A. T., Öcal, G., Berberoglu, M., Tekin, M., Kiliç, B. G., Aycan, Z., Kutlu, A., Adiyaman, P., Siklar, Z., Akar, N., Sahin, A., & Akçayöz, D. (2008). Paternal X could relate to arithmetic function; study of cognitive function and parental origin of X chromosome in Turner syndrome. Pediatrics International, 50(2), 172-174. https://doi.org/10.1111/j.1442-200X.2008.02540.x