Patching vs atropine to treat amblyopia in children aged 7 to 12 years: A randomized trial

Mitchell M. Scheiman, Richard W. Hertle, Raymond T. Kraker, Roy W. Beck, Eileen E. Birch, Joost Felius, Jonathan M. Holmes, James Kundart, David G. Morrison, Michael X. Repka, Susanna Tamkins

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective: To compare patching with atropine eye-drops in the treatment of moderate amblyopia (visual acuity, 20/40-20/100) in children aged 7 to 12 years. Methods: In a randomized, multicenter clinical trial, 193 children with amblyopia were assigned to receive weekend atropine or patching of the sound eye 2 hours per day. Main Outcome Measure: Masked assessment of visual acuity in the amblyopic eye using the electronic Early Treatment Diabetic Retinopathy Study testing protocol at 17 weeks. Results: At 17 weeks, visual acuity had improved from baseline by an average of 7.6 letters in the atropine group and 8.6 letters in the patching group. The mean difference between groups (patching - atropine) adjusted for baseline acuity was 1.2 letters (ends of complementary 1-sided 95% confidence intervals for noninferiority, -0.7, 3.1 letters). This difference met the prespecified definition for equivalence (confidence interval

Original languageEnglish (US)
Pages (from-to)1634-1642
Number of pages9
JournalArchives of Ophthalmology
Volume126
Issue number12
DOIs
StatePublished - Dec 2008

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Amblyopia
Atropine
Visual Acuity
Confidence Intervals
Ophthalmic Solutions
Diabetic Retinopathy
Multicenter Studies
Randomized Controlled Trials
Outcome Assessment (Health Care)
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Scheiman, M. M., Hertle, R. W., Kraker, R. T., Beck, R. W., Birch, E. E., Felius, J., ... Tamkins, S. (2008). Patching vs atropine to treat amblyopia in children aged 7 to 12 years: A randomized trial. Archives of Ophthalmology, 126(12), 1634-1642. https://doi.org/10.1001/archophthalmol.2008.107

Patching vs atropine to treat amblyopia in children aged 7 to 12 years : A randomized trial. / Scheiman, Mitchell M.; Hertle, Richard W.; Kraker, Raymond T.; Beck, Roy W.; Birch, Eileen E.; Felius, Joost; Holmes, Jonathan M.; Kundart, James; Morrison, David G.; Repka, Michael X.; Tamkins, Susanna.

In: Archives of Ophthalmology, Vol. 126, No. 12, 12.2008, p. 1634-1642.

Research output: Contribution to journalArticle

Scheiman, MM, Hertle, RW, Kraker, RT, Beck, RW, Birch, EE, Felius, J, Holmes, JM, Kundart, J, Morrison, DG, Repka, MX & Tamkins, S 2008, 'Patching vs atropine to treat amblyopia in children aged 7 to 12 years: A randomized trial', Archives of Ophthalmology, vol. 126, no. 12, pp. 1634-1642. https://doi.org/10.1001/archophthalmol.2008.107
Scheiman, Mitchell M. ; Hertle, Richard W. ; Kraker, Raymond T. ; Beck, Roy W. ; Birch, Eileen E. ; Felius, Joost ; Holmes, Jonathan M. ; Kundart, James ; Morrison, David G. ; Repka, Michael X. ; Tamkins, Susanna. / Patching vs atropine to treat amblyopia in children aged 7 to 12 years : A randomized trial. In: Archives of Ophthalmology. 2008 ; Vol. 126, No. 12. pp. 1634-1642.
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