Background: In recent years, it has been shown that patients with atopic dermatitis frequently present positive patch tests to dust mite components. Objective: The aim of this study was to evaluate a new patch test system that consists of a mixture of Dermatophagoides pteronyssinus- and Dermatophagoides farinae-purified adult mite bodies (Allergopharma-Bracco, Milano, Italy) in the study of patients with atopic dermatitis. Methods: From January 1992 to April 1993, we patch tested with mite extracts 71 adults (31 men and 40 women ranging in age from 13 to 68 years; average, 26.7%) and 15 children (7 boys and 8 girls ranging in age from 2 to 12 years; average, 7.4%) affected by atopic dermatitis. Patch tests were performed according to the International Contact Dermatitis Research Group recommendations using Finn chambers on Scanpor tape. Results: Twenty-six adults (36.6%) and 11 children (73%) showed a positive erythematovesicular reaction at 48 and 72 hours. Seventeen of these patients (5 children and 12 adults) also showed a positive prick test reaction to mite extracts. Nine of the positive patch test reactions to mite extracts were judged to be clinically relevant. All of these patients improved after dust mite avoidance. Conclusions: Patch tests with dust mites can be important to identify mite-hypersensitive patients, even when prick tests with mite extracts are negative. Our results confirm the view that skin lesions of atopic dermatitis may be partially caused or at least worsened by delayed hypersensitivity to mite bodies.
|Original language||English (US)|
|Number of pages||3|
|Journal||American Journal of Contact Dermatitis|
|State||Published - Dec 1 1994|
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