Abstract
This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents; each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10, budesonide 0.002, and tixocortol pivalate, both concentrations (1.0 and 0.10) tracing the same number. With the mixes, 53.2-59.6 of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25 of these only to 1.0 and another 25 only to 0.10. Testing with mix I and tixocortol pivalate 0.10 picked up 98/110, testing with tixocortol pivalate 1.0 and 0.10 and budesonide 0.10 picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30 of contact allergy to corticosteroid markers was missed.
| Original language | English |
|---|---|
| Pages (from-to) | 27-35 |
| Number of pages | 9 |
| Journal | Contact Dermatitis |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 29 2000 |
| Externally published | Yes |
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Keywords
- Budesonide
- Contact allergy
- Corticosteroids
- Hydrocortisone-17-butyrate
- Medicaments
- Mixes
- Patch testing technique
- Tixocortol pivalate
ASJC Scopus subject areas
- Dermatology
- Toxicology
- Immunology
Cite this
Patch testing with corticosteroid mixes in Europe. A multicentre study of the EECDRG. / Isaksson, Marléne; Andersen, K. E.; Brandão, F. M.; Bruynzeel, D. P.; Bruze, M.; Camarasa, J. G.; Diepgen, T.; Ducombs, G.; Frosch, P. J.; Goossens, A.; Lahti, A.; Menné, T.; Rycroft, R. J G; Seidenari, S.; Shaw, S.; Tosti, Antonella; Wahlberg, J.; White, I. R.; Wilkinson, J. D.
In: Contact Dermatitis, Vol. 42, No. 1, 29.01.2000, p. 27-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Patch testing with corticosteroid mixes in Europe. A multicentre study of the EECDRG
AU - Isaksson, Marléne
AU - Andersen, K. E.
AU - Brandão, F. M.
AU - Bruynzeel, D. P.
AU - Bruze, M.
AU - Camarasa, J. G.
AU - Diepgen, T.
AU - Ducombs, G.
AU - Frosch, P. J.
AU - Goossens, A.
AU - Lahti, A.
AU - Menné, T.
AU - Rycroft, R. J G
AU - Seidenari, S.
AU - Shaw, S.
AU - Tosti, Antonella
AU - Wahlberg, J.
AU - White, I. R.
AU - Wilkinson, J. D.
PY - 2000/1/29
Y1 - 2000/1/29
N2 - This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents; each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10, budesonide 0.002, and tixocortol pivalate, both concentrations (1.0 and 0.10) tracing the same number. With the mixes, 53.2-59.6 of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25 of these only to 1.0 and another 25 only to 0.10. Testing with mix I and tixocortol pivalate 0.10 picked up 98/110, testing with tixocortol pivalate 1.0 and 0.10 and budesonide 0.10 picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30 of contact allergy to corticosteroid markers was missed.
AB - This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents; each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10, budesonide 0.002, and tixocortol pivalate, both concentrations (1.0 and 0.10) tracing the same number. With the mixes, 53.2-59.6 of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25 of these only to 1.0 and another 25 only to 0.10. Testing with mix I and tixocortol pivalate 0.10 picked up 98/110, testing with tixocortol pivalate 1.0 and 0.10 and budesonide 0.10 picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30 of contact allergy to corticosteroid markers was missed.
KW - Budesonide
KW - Contact allergy
KW - Corticosteroids
KW - Hydrocortisone-17-butyrate
KW - Medicaments
KW - Mixes
KW - Patch testing technique
KW - Tixocortol pivalate
UR - http://www.scopus.com/inward/record.url?scp=0033955175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033955175&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0536.2000.042001027.x
DO - 10.1034/j.1600-0536.2000.042001027.x
M3 - Article
VL - 42
SP - 27
EP - 35
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 1
ER -