Patch testing with corticosteroid mixes in Europe. A multicentre study of the EECDRG

Marléne Isaksson, K. E. Andersen, F. M. Brandão, D. P. Bruynzeel, M. Bruze, J. G. Camarasa, T. Diepgen, G. Ducombs, P. J. Frosch, A. Goossens, A. Lahti, T. Menné, R. J.G. Rycroft, S. Seidenari, S. Shaw, A. Tosti, J. Wahlberg, I. R. White, J. D. Wilkinson

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents; each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10, budesonide 0.002, and tixocortol pivalate, both concentrations (1.0 and 0.10) tracing the same number. With the mixes, 53.2-59.6 of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25 of these only to 1.0 and another 25 only to 0.10. Testing with mix I and tixocortol pivalate 0.10 picked up 98/110, testing with tixocortol pivalate 1.0 and 0.10 and budesonide 0.10 picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30 of contact allergy to corticosteroid markers was missed.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalContact dermatitis
Volume42
Issue number1
DOIs
StatePublished - 2000

Keywords

  • Budesonide
  • Contact allergy
  • Corticosteroids
  • Hydrocortisone-17-butyrate
  • Medicaments
  • Mixes
  • Patch testing technique
  • Tixocortol pivalate

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

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    Isaksson, M., Andersen, K. E., Brandão, F. M., Bruynzeel, D. P., Bruze, M., Camarasa, J. G., Diepgen, T., Ducombs, G., Frosch, P. J., Goossens, A., Lahti, A., Menné, T., Rycroft, R. J. G., Seidenari, S., Shaw, S., Tosti, A., Wahlberg, J., White, I. R., & Wilkinson, J. D. (2000). Patch testing with corticosteroid mixes in Europe. A multicentre study of the EECDRG. Contact dermatitis, 42(1), 27-35. https://doi.org/10.1034/j.1600-0536.2000.042001027.x