Abstract
The effects of the superactive agonist analog D-Trp-6-LH-RH were investigated in several neuropharmacological tests: inhibition of picrotoxin-induced seizures, open-field behavior, hot-plate and tail-flick tests, assessment of catalepsy and apomorphine-induced cage-climbing. In most tests, D-Trp-6-LH-RH was administered subcutaneously (sc.) at the dose of 100 μg/kg. The opiate involvement in the peptide action was checked by using naloxone HCl (NX) in a dose of 1 mg/kg intraperitoneally (ip.), with the exception of the analgesic tests where the dose was 0.5 mg/kg. The analog significantly suppressed the open-field parameters of ambulation, rearing and grooming; except for grooming, these actions were fully antagonized by NX. Similarly, NX pretreatment restored to the control levels the latencies of seizure parameters increased by D-Trp-6-LH-RH. The hot-plate latencies did not change after pretreatment with NX but the opiate antagonist was fully able to antagonize the analgesic effect of the peptide in the tail-flick test. The cataleptogenic effect and the inhibition of apomorphine-induced cage--climbing demonstrated after D-Trp-LH-RH were not antagonized by NX.
| Original language | English |
|---|---|
| Pages (from-to) | 463-470 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Partial reversal of behavioral action of the agonist D-Trp-6-LH-RH by naloxone in mice. / Kádár, Tibor; Telegdy, Gyula; Schally, Andrew V.
In: Life Sciences, Vol. 46, No. 7, 01.01.1990, p. 463-470.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Partial reversal of behavioral action of the agonist D-Trp-6-LH-RH by naloxone in mice
AU - Kádár, Tibor
AU - Telegdy, Gyula
AU - Schally, Andrew V
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The effects of the superactive agonist analog D-Trp-6-LH-RH were investigated in several neuropharmacological tests: inhibition of picrotoxin-induced seizures, open-field behavior, hot-plate and tail-flick tests, assessment of catalepsy and apomorphine-induced cage-climbing. In most tests, D-Trp-6-LH-RH was administered subcutaneously (sc.) at the dose of 100 μg/kg. The opiate involvement in the peptide action was checked by using naloxone HCl (NX) in a dose of 1 mg/kg intraperitoneally (ip.), with the exception of the analgesic tests where the dose was 0.5 mg/kg. The analog significantly suppressed the open-field parameters of ambulation, rearing and grooming; except for grooming, these actions were fully antagonized by NX. Similarly, NX pretreatment restored to the control levels the latencies of seizure parameters increased by D-Trp-6-LH-RH. The hot-plate latencies did not change after pretreatment with NX but the opiate antagonist was fully able to antagonize the analgesic effect of the peptide in the tail-flick test. The cataleptogenic effect and the inhibition of apomorphine-induced cage--climbing demonstrated after D-Trp-LH-RH were not antagonized by NX.
AB - The effects of the superactive agonist analog D-Trp-6-LH-RH were investigated in several neuropharmacological tests: inhibition of picrotoxin-induced seizures, open-field behavior, hot-plate and tail-flick tests, assessment of catalepsy and apomorphine-induced cage-climbing. In most tests, D-Trp-6-LH-RH was administered subcutaneously (sc.) at the dose of 100 μg/kg. The opiate involvement in the peptide action was checked by using naloxone HCl (NX) in a dose of 1 mg/kg intraperitoneally (ip.), with the exception of the analgesic tests where the dose was 0.5 mg/kg. The analog significantly suppressed the open-field parameters of ambulation, rearing and grooming; except for grooming, these actions were fully antagonized by NX. Similarly, NX pretreatment restored to the control levels the latencies of seizure parameters increased by D-Trp-6-LH-RH. The hot-plate latencies did not change after pretreatment with NX but the opiate antagonist was fully able to antagonize the analgesic effect of the peptide in the tail-flick test. The cataleptogenic effect and the inhibition of apomorphine-induced cage--climbing demonstrated after D-Trp-LH-RH were not antagonized by NX.
UR - http://www.scopus.com/inward/record.url?scp=0025141722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025141722&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(90)90001-8
DO - 10.1016/0024-3205(90)90001-8
M3 - Article
C2 - 2137549
AN - SCOPUS:0025141722
VL - 46
SP - 463
EP - 470
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 7
ER -