Partial reversal of behavioral action of the agonist D-Trp-6-LH-RH by naloxone in mice

Tibor Kádár, Gyula Telegdy, Andrew V Schally

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of the superactive agonist analog D-Trp-6-LH-RH were investigated in several neuropharmacological tests: inhibition of picrotoxin-induced seizures, open-field behavior, hot-plate and tail-flick tests, assessment of catalepsy and apomorphine-induced cage-climbing. In most tests, D-Trp-6-LH-RH was administered subcutaneously (sc.) at the dose of 100 μg/kg. The opiate involvement in the peptide action was checked by using naloxone HCl (NX) in a dose of 1 mg/kg intraperitoneally (ip.), with the exception of the analgesic tests where the dose was 0.5 mg/kg. The analog significantly suppressed the open-field parameters of ambulation, rearing and grooming; except for grooming, these actions were fully antagonized by NX. Similarly, NX pretreatment restored to the control levels the latencies of seizure parameters increased by D-Trp-6-LH-RH. The hot-plate latencies did not change after pretreatment with NX but the opiate antagonist was fully able to antagonize the analgesic effect of the peptide in the tail-flick test. The cataleptogenic effect and the inhibition of apomorphine-induced cage--climbing demonstrated after D-Trp-LH-RH were not antagonized by NX.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalLife Sciences
Volume46
Issue number7
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Triptorelin Pamoate
Naloxone
Opiate Alkaloids
Grooming
Apomorphine
Analgesics
Tail
Seizures
Catalepsy
Picrotoxin
Peptides
Level control
Gonadotropin-Releasing Hormone
Walking

ASJC Scopus subject areas

  • Pharmacology

Cite this

Partial reversal of behavioral action of the agonist D-Trp-6-LH-RH by naloxone in mice. / Kádár, Tibor; Telegdy, Gyula; Schally, Andrew V.

In: Life Sciences, Vol. 46, No. 7, 01.01.1990, p. 463-470.

Research output: Contribution to journalArticle

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