Parkinson's disease and brain levels of organochlorine pesticides

Lora Fleming, John B. Mann, Judy Bean, Thomas Briggle, Juan R. Sanchez-Ramos

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Epidemiological studies have suggested an etiologic relationship between pesticide exposure and Parkinson's disease (PD). Organochlorine pesticides were assayed in postmortem brain samples from 20 PD, 7 Alzheimer's disease (AD), and 14 nonneurological control cases. The three groups were similar in age at death, sex, and demographic variables. Only two of 16 pesticide residues screened were detected. A long-lasting residue of DDT (pp-DDE) was found in the majority of cases of PD and AD, as well as in all the control cases; pp-DDT was significantly more likely to be found in AD controls than the PD cases (Fisher's exact two-tailed, p = 0.04). Dieldrin was detected in 6 of 20 PD brains, 1 of 7 AD, and in none of 14 control samples. Despite the relatively small number of brains assayed, the association between Dieldrin and the diagnosis of PD was highly significant (p = 0.03). Dieldrin, a lipid- soluble, long-lasting mitochondrial poison, should be investigated as a potential etiological agent of Parkinsonism.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalAnnals of Neurology
Issue number1
StatePublished - Jul 1 1994
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fleming, L., Mann, J. B., Bean, J., Briggle, T., & Sanchez-Ramos, J. R. (1994). Parkinson's disease and brain levels of organochlorine pesticides. Annals of Neurology, 36(1), 100-103.