Parkinson's disease and brain levels of organochlorine pesticides

Lora Fleming, John B. Mann, Judy Bean, Thomas Briggle, Juan R. Sanchez-Ramos

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Epidemiological studies have suggested an etiologic relationship between pesticide exposure and Parkinson's disease (PD). Organochlorine pesticides were assayed in postmortem brain samples from 20 PD, 7 Alzheimer's disease (AD), and 14 nonneurological control cases. The three groups were similar in age at death, sex, and demographic variables. Only two of 16 pesticide residues screened were detected. A long-lasting residue of DDT (pp-DDE) was found in the majority of cases of PD and AD, as well as in all the control cases; pp-DDT was significantly more likely to be found in AD controls than the PD cases (Fisher's exact two-tailed, p = 0.04). Dieldrin was detected in 6 of 20 PD brains, 1 of 7 AD, and in none of 14 control samples. Despite the relatively small number of brains assayed, the association between Dieldrin and the diagnosis of PD was highly significant (p = 0.03). Dieldrin, a lipid- soluble, long-lasting mitochondrial poison, should be investigated as a potential etiological agent of Parkinsonism.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalAnnals of Neurology
Volume36
Issue number1
DOIs
StatePublished - Jul 1 1994
Externally publishedYes

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Pesticides
Parkinson Disease
Dieldrin
Brain
DDT
Alzheimer Disease
Dichlorodiphenyl Dichloroethylene
Pesticide Residues
Poisons
Parkinsonian Disorders
Epidemiologic Studies
Demography
Lipids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fleming, L., Mann, J. B., Bean, J., Briggle, T., & Sanchez-Ramos, J. R. (1994). Parkinson's disease and brain levels of organochlorine pesticides. Annals of Neurology, 36(1), 100-103. https://doi.org/10.1002/ana.410360119

Parkinson's disease and brain levels of organochlorine pesticides. / Fleming, Lora; Mann, John B.; Bean, Judy; Briggle, Thomas; Sanchez-Ramos, Juan R.

In: Annals of Neurology, Vol. 36, No. 1, 01.07.1994, p. 100-103.

Research output: Contribution to journalArticle

Fleming, L, Mann, JB, Bean, J, Briggle, T & Sanchez-Ramos, JR 1994, 'Parkinson's disease and brain levels of organochlorine pesticides', Annals of Neurology, vol. 36, no. 1, pp. 100-103. https://doi.org/10.1002/ana.410360119
Fleming L, Mann JB, Bean J, Briggle T, Sanchez-Ramos JR. Parkinson's disease and brain levels of organochlorine pesticides. Annals of Neurology. 1994 Jul 1;36(1):100-103. https://doi.org/10.1002/ana.410360119
Fleming, Lora ; Mann, John B. ; Bean, Judy ; Briggle, Thomas ; Sanchez-Ramos, Juan R. / Parkinson's disease and brain levels of organochlorine pesticides. In: Annals of Neurology. 1994 ; Vol. 36, No. 1. pp. 100-103.
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