Parkinson disease loci in the mid-western Amish

M. F. Davis, A. C. Cummings, L. N. D'Aoust, L. Jiang, D. R. Velez Edwards, R. Laux, L. Reinhart-Mercer, D. Fuzzell, W. K. Scott, M. A. Pericak-Vance, S. L. Lee, J. L. Haines

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Previous evidence has shown that Parkinson disease (PD) has a heritable component, but only a small proportion of the total genetic contribution to PD has been identified. Genetic heterogeneity complicates the verification of proposed PD genes and the identification of new PD susceptibility genes. Our approach to overcome the problem of heterogeneity is to study a population isolate, the mid-western Amish communities of Indiana and Ohio. We performed genome-wide association and linkage analyses on 798 individuals (31 with PD), who are part of a 4,998 member pedigree. Through these analyses, we identified a region on chromosome 5q31.3 that shows evidence of association (p value < 1 × 10-4) and linkage (multipoint HLOD = 3.77). We also found further evidence of linkage on chromosomes 6 and 10 (multipoint HLOD 4.02 and 4.35 respectively). These data suggest that locus heterogeneity, even within the Amish, may be more extensive than previously appreciated.

Original languageEnglish (US)
Pages (from-to)1213-1221
Number of pages9
JournalHuman genetics
Volume132
Issue number11
DOIs
StatePublished - Nov 2013

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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