Paricalcitol downregulates myocardial renin-angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats

Michael Freundlich, Yan C. Li, Yasmir Quiroz, Yanauri Bravo, Wacharee Seeherunvong, Christian Faul, Jose R. Weisinger, Bernardo Rodriguez-Iturbe

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

BACKGROUND Vitamin D attenuates uremic cardiac hypertrophy, possibly by suppressing the myocardial renin-angiotensin system (RAS) and fibroblast growth factors (FGFs). We compared the suppression of cardiac hypertrophy and myocardial expression of RAS and FGF receptor genes offered by the vitamin D analog paricalcitol (Pc) or the angiotensin-converting enzyme inhibitor enalapril (E) in experimental uremia. METHODS Rats with 5/6 nephrectomy received Pc or E for 8 weeks. Renal function, systolic blood pressure, and cardiac hypertrophy were evaluated. Myocardial expression of RAS genes, brain natriuretic peptide (BNP), and FGF receptor-1 (FGFR-1) were determined using quantitative reverse-transcription (pRT)-PCR. RESULTS Blood pressure, proteinuria, and serum creatinine were significantly higher in untreated uremic animals. Hypertension was significantly reduced by E but only modestly by Pc; however, cardiac hypertrophy in the untreated group was similarly attenuated by Pc or E. Upregulation of myocardial expressions of renin, angiotensinogen, FGFR-1, and BNP in untreated uremic animals was reduced similarly by Pc and E, while the angiotensin II type 1 receptor was downregulated only by E. CONCLUSIONS Uremic cardiac hypertrophy is associated with activation of the myocardial RAS and the FGFR-1. Downregulation of these genes induced by Pc and E RESULTS in similar amelioration of left ventricular hypertrophy despite the different antihypertensive effects of these drugs.

Original languageEnglish (US)
Pages (from-to)720-726
Number of pages7
JournalAmerican Journal of Hypertension
Volume27
Issue number5
DOIs
StatePublished - Jan 1 2014

Keywords

  • cardiac hypertrophy
  • fibroblast growth factor
  • paricalcitol.
  • renin-angiotensin system
  • uremia
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Paricalcitol downregulates myocardial renin-angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats'. Together they form a unique fingerprint.

  • Cite this