Pargyline‐Sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia

S. M.N. Efange, H. F. Kung, D. C. Mash, M. Jabir, J. Billings, J. Pablo, A. Dutta, A. Freshler

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The distribution of radioiodinated N-methyl-4-(4-hydroxy-3-iodobenzyl)-1,2,3,6-tetrahydropyridine (MHTP), an analog of the reportedly nontoxic N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, (4-homo-MPTP), has been studied in the primate. [123I]MHTP-derived radioactivity exhibited a progressive accumulation and prolonged retention within the primate eye. Following iv injection, [123I]MHTP-rapidly accumulated within the primate brain and was subsequently oxidized to a radiolabeled metabolite. The half-life of [123I]MHTP-derived radioactivity within the primate brain was 50 min. The highest concentrations of radioactivity were found in the caudate-putamen and the frontal, temporal and cingulate cortices; the substantia nigra and inferior olivary nucleus were labeled with medium intensity. Very low concentrations of radiolabel were detected in the cerebellum and white matter. Selective accumulation of [125I]MHTP-derived radioactivity within these structures was blocked by pretreatment with pargyline, suggesting that monoamine oxidase B is involved in the bioactivation of radioiodinated MHTP.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalSynapse
Volume5
Issue number3
DOIs
StatePublished - 1990

Keywords

  • 4‐Homo‐MPTP
  • MHTP
  • Monoamine oxidase
  • [I]MHTP

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Efange, S. M. N., Kung, H. F., Mash, D. C., Jabir, M., Billings, J., Pablo, J., Dutta, A., & Freshler, A. (1990). Pargyline‐Sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia. Synapse, 5(3), 207-212. https://doi.org/10.1002/syn.890050306