Abstract
Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.
| Original language | English |
|---|---|
| Pages (from-to) | 7-20 |
| Number of pages | 14 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1974 |
| Externally published | Yes |
Fingerprint
Keywords
- cAMP
- gonadotropins
- LH-RH
- pituitary
- releasing factors
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro. / Borgeat, P.; Labrie, F.; Côté, J.; Ruel, F.; Schally, Andrew V; Coy, D. H.; Coy, E. J.; Yanaihara, N.
In: Molecular and Cellular Endocrinology, Vol. 1, No. 1, 01.01.1974, p. 7-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro
AU - Borgeat, P.
AU - Labrie, F.
AU - Côté, J.
AU - Ruel, F.
AU - Schally, Andrew V
AU - Coy, D. H.
AU - Coy, E. J.
AU - Yanaihara, N.
PY - 1974/1/1
Y1 - 1974/1/1
N2 - Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.
AB - Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.
KW - cAMP
KW - gonadotropins
KW - LH-RH
KW - pituitary
KW - releasing factors
UR - http://www.scopus.com/inward/record.url?scp=0011911058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0011911058&partnerID=8YFLogxK
U2 - 10.1016/0303-7207(74)90035-5
DO - 10.1016/0303-7207(74)90035-5
M3 - Article
VL - 1
SP - 7
EP - 20
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1
ER -