Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro

P. Borgeat; F. Labrie; J. Côté; F. Ruel; A. V. Schally; D. H. Coy; E. J. Coy; N. Yanaihara

doi:10.1016/0303-7207(74)90035-5

Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro

P. Borgeat, F. Labrie, J. Côté, F. Ruel, A. V. Schally, D. H. Coy, E. J. Coy, N. Yanaihara

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Dose-response studies with des-(pyro) Glu-LH-RH, [Phe³] LH-RH, [Phe⁵] LH-RH [0-methyl-Tyr⁵] LH-RH, [Ile⁷] LH-RH and des-Gly¹⁰-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His²-des-Gly¹⁰-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.

Original language	English (US)
Pages (from-to)	7-20
Number of pages	14
Journal	Molecular and Cellular Endocrinology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0303-7207(74)90035-5
State	Published - Mar 1974
Externally published	Yes

Keywords

cAMP
gonadotropins
LH-RH
pituitary
releasing factors

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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title = "Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro",

abstract = "Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.",

keywords = "cAMP, gonadotropins, LH-RH, pituitary, releasing factors",

author = "P. Borgeat and F. Labrie and J. C{\^o}t{\'e} and F. Ruel and Schally, {A. V.} and Coy, {D. H.} and Coy, {E. J.} and N. Yanaihara",

year = "1974",

month = mar,

doi = "10.1016/0303-7207(74)90035-5",

language = "English (US)",

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T1 - Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro

AU - Borgeat, P.

AU - Labrie, F.

AU - Côté, J.

AU - Ruel, F.

AU - Schally, A. V.

AU - Coy, D. H.

AU - Coy, E. J.

AU - Yanaihara, N.

PY - 1974/3

Y1 - 1974/3

N2 - Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.

AB - Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.

KW - cAMP

KW - gonadotropins

KW - LH-RH

KW - pituitary

KW - releasing factors

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JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

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ER -

Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro

Abstract

Keywords

ASJC Scopus subject areas

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