Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro

P. Borgeat, F. Labrie, J. Côté, F. Ruel, A. V. Schally, D. H. Coy, E. J. Coy, N. Yanaihara

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Dose-response studies with des-(pyro) Glu-LH-RH, [Phe3] LH-RH, [Phe5] LH-RH [0-methyl-Tyr5] LH-RH, [Ile7] LH-RH and des-Gly10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His2-des-Gly10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.

Original languageEnglish (US)
Pages (from-to)7-20
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume1
Issue number1
DOIs
StatePublished - Mar 1974
Externally publishedYes

Keywords

  • cAMP
  • gonadotropins
  • LH-RH
  • pituitary
  • releasing factors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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