Parainfectious optic neuritis and encephalomyelitis: A report of two cases with thalamic involvement

Latif M. Hamed, Jonathan Silbiger, John Guy, J. Parker Mickle, Patrick Sibony, Alfred Cossari, Mary Andriola

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Two children developed mental status alteration and bilateral profound visual loss secondary to optic neuritis. The clinical picture was consistent with parainfectious encephalomyelitis. Magnetic resonance imaging showed bilateral involvement of the thalamus in both cases. In one case the thalamic involvement was solitary and was suspected initially to represent a primary thalamic neoplasm. This was ruled out by a stereotactic biopsy of the thalamus, which showed perivascular inflammation consistent with parainfectious encephalomyelitis. The clinical and neuroimaging findings improved significantly following corticosteroid administration. Several relapses occurred upon initial attempts at corticosteroid cessation.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalJournal of Clinical Neuro-Ophthalmology
Issue number1
StatePublished - Mar 1993
Externally publishedYes


  • Corticosteroid therapy
  • Encephalitis
  • Neuroimaging
  • Thalamus

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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