Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamic-pituitary-gonadal axis in immature female rats

J. A. Vilchez-Martinez, E. Pedroza, A. Arimura, Andrew V Schally

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effect of administration of a superactive and long-acting analog of luteinizing hormone-releasing hormone (LH-RH), D-Trp6-LH-RH, in doses of 0.05 or 1 μg/day for 10 days on the hypothalamic-pituitary-gonadal axis was studied in immature female rats. Treatment with a 0.05-μg dose of analog produced few changes as compared with the control group. Treatment with 1 μg of D-Trp6-LH-RH did not affect the body weight or the pituitary weight, but increased ovarian weight and decreased uterine weight; elevated serum gonadotropin levels; and lowered the pituitary LH content. This depletion of pituitary LH content was associated with a low pituitary responsiveness to LH-RH. Serum estradiol levels were not modified, suggesting that decreased uterine weight reflects a direct and extrapituitary effect of this analog. The hypothalamic LH-RH content was higher, indicating a possible inhibition of the release of endogenous LH-RH. A delay in vaginal opening was also observed. This indicates that large doses of D-Trp6-LH-RH may interfere with the process of puberty in rats. These findings extend other reports about the paradoxical antifertility effects of large doses of stimulatory analogs of LH-RH.

Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalFertility and Sterility
Volume31
Issue number6
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Weights and Measures
Hypothalamic Hormones
Puberty
Serum
Gonadotropins
Estradiol
Body Weight
Control Groups

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamic-pituitary-gonadal axis in immature female rats. / Vilchez-Martinez, J. A.; Pedroza, E.; Arimura, A.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 31, No. 6, 01.01.1979, p. 677-682.

Research output: Contribution to journalArticle

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