Paradigm Shift in Utilization of Livers from Hepatitis C–Viremic Donors into Hepatitis C Virus–Negative Patients

Eric F. Martin

doi:10.1016/j.cld.2020.08.009

Paradigm Shift in Utilization of Livers from Hepatitis C–Viremic Donors into Hepatitis C Virus–Negative Patients

Eric F. Martin

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded.

Original language	English (US)
Pages (from-to)	195-207
Number of pages	13
Journal	Clinics in liver disease
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.cld.2020.08.009
State	Published - Feb 2021

Keywords

HCV-positive donor
HCV-viremic donor
Hepatitis C virus
Liver transplantation

ASJC Scopus subject areas

Hepatology

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title = "Paradigm Shift in Utilization of Livers from Hepatitis C–Viremic Donors into Hepatitis C Virus–Negative Patients",

abstract = "Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded.",

keywords = "HCV-positive donor, HCV-viremic donor, Hepatitis C virus, Liver transplantation",

author = "Martin, {Eric F.}",

note = "Funding Information: The author has nothing to disclose.",

year = "2021",

month = feb,

doi = "10.1016/j.cld.2020.08.009",

language = "English (US)",

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journal = "Clinics in Liver Disease",

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T1 - Paradigm Shift in Utilization of Livers from Hepatitis C–Viremic Donors into Hepatitis C Virus–Negative Patients

AU - Martin, Eric F.

N1 - Funding Information: The author has nothing to disclose.

PY - 2021/2

Y1 - 2021/2

N2 - Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded.

AB - Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded.

KW - HCV-positive donor

KW - HCV-viremic donor

KW - Hepatitis C virus

KW - Liver transplantation

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