Paracrine and autocrine interactions in the human islet

More than meets the eye

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The pancreatic islet secretes the hormones insulin and glucagon to regulate glucose metabolism. To generate an adequate secretory response, islet endocrine cells must receive multiple regulatory signals relaying information about changes in the internal and external environments. Islet cells also need to be made aware about the functional status of neighboring cells through paracrine interactions. All this information is used to orchestrate a hormonal response that contributes to glucose homeostasis. Several neurotransmitters have been proposed to work as paracrine signals in the islet. Most of these, however, have yet to meet the criteria to be considered bona fide paracrine signals, in particular in human islets. Here, we review recent findings describing autocrine and paracrine signaling mechanisms in human islets. These recent results are showing an increasingly complex picture of paracrine interactions in the human islet and emphasize that results from other species cannot be readily extrapolated to the human context. Investigators are unveiling new signaling mechanisms or finding new roles for known paracrine signals in human islets. While it is too early to provide a synthesis, the field of islet research is defining the paracrine and autocrine components that will be used to generate models about how islet function is regulated. Meanwhile, the identified signaling pathways can be proposed as therapeutic targets for treating diabetes, a devastating disease affecting millions worldwide.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Islets of Langerhans
Autocrine Communication
Paracrine Communication
Glucose
Endocrine Cells
Glucagon
Neurotransmitter Agents
Homeostasis
Research Personnel
Hormones
Insulin
Research
Therapeutics

Keywords

  • Diabetes
  • Glucagon
  • Insulin
  • Pancreatic islet
  • Paracrine

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Paracrine and autocrine interactions in the human islet : More than meets the eye. / Caicedo-Vierkant, Diego A.

In: Seminars in Cell and Developmental Biology, Vol. 24, No. 1, 01.01.2013, p. 11-21.

Research output: Contribution to journalArticle

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