Papuloerythroderma 2009: Two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al.

Daniele Torchia, Mariya Miteva, Shasa Hu, Carlos Cohen, Paolo Romanelli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Even after the description of papuloerythroderma of Ofuji (PEO) in 1984, little is known about this clinical entity. Objective:To report on 2 new cases of PEO and review of the worldwide literature on this topic. Methods: Article citations were searched on several biomedical search engines (PubMed, EMBASE, SCOPUS, Google Scholar). Papers were retrieved either online or in print. Results: A grand total of 170 PEO cases were identified. Most patients were older than 55 years and of Asian or white descent, with an overall male/female ratio of 4.0. Itch and the deck-chair sign were observed in all patients. Peripheral eosinophilia, lymphocytopenia and increased serum IgE were common findings. Histopathology mostly showed aspecific inflammation, while 17 showed histological features of cutaneous T-cell lymphoma (CTCL). Atopy, malignancies, infections and drugs were rarely linked to PEO. Conclusion: PEO represents a rather monomorphous entity both clinically and, with the remarkable exception of CTCL, also histologically. Nonetheless, no causative factor could be identified in the vast majority of cases. An etiological classification and diagnostic criteria are proposed in the attempt to contribute framing this puzzling clinical entity.

Original languageEnglish
Pages (from-to)311-320
Number of pages10
JournalDermatology
Volume220
Issue number4
DOIs
StatePublished - Jun 1 2010

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Cutaneous T-Cell Lymphoma
Search Engine
Lymphopenia
Eosinophilia
PubMed
Immunoglobulin E
Inflammation
Infection
Serum
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cutaneous T-cell lymphoma
  • Deck-chair sign
  • Papuloerythroderma of Ofuji

ASJC Scopus subject areas

  • Dermatology

Cite this

Papuloerythroderma 2009 : Two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al. / Torchia, Daniele; Miteva, Mariya; Hu, Shasa; Cohen, Carlos; Romanelli, Paolo.

In: Dermatology, Vol. 220, No. 4, 01.06.2010, p. 311-320.

Research output: Contribution to journalArticle

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