Papillon‐Lefèvre Syndrome

R. Kenneth Landow, Herman Cheung, Marjorie Bauer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A patient, with Papillon-Lefevre syndrome, presented with a premature loss of both deciduous and permanent teeth and hyperkeratosis palmaris et plantaris. Other abnormalities such as psoriasiform hyperkeratosis, calcification of the falx, and frequent infections can be seen. Although no etiologic factor is known for this aberration, an autosomal recessive inheritance is established. Treatment usually consists of dental hygiene only since dermatologic therapy is usually unrewarding. A new finding resulted when fibroblasts from involved gingiva were compared with either uninvolved gingiva or controlled gingiva. The protein and collagen synthesis of the involved tissue was about twice that of the latter two groups.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalInternational journal of dermatology
Issue number3
StatePublished - Apr 1983
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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