Pannexins and gap junction protein diversity

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ formation. Another family of GJ proteins (innexins) were first found in invertebrates and were proposed to be renamed pannexins after their orthologs were discovered in vertebrates. The lack of both connexins and pannexins in the genomes of some metazoans suggests that other, still undiscovered GJ proteins exist. In vertebrates, connexins and pannexins co-exist. Here we discuss whether vertebrate pannexins have a nonredundant role in animal physiology. Pannexin channels appear to be suited for ATP and calcium signaling and play a role in the maintenance of calcium homeostasis by mechanisms implicating both GJ and nonjunctional function. Suggested roles in the ischemic death of neurons, schizophrenia, inflammation and tumor suppression have drawn much attention to exploring the molecular properties and cellular functions of pannexins.

Original languageEnglish
Pages (from-to)376-394
Number of pages19
JournalCellular and Molecular Life Sciences
Volume65
Issue number3
DOIs
StatePublished - Feb 1 2008

Fingerprint

Connexins
Vertebrates
Calcium
Calcium Signaling
Gap Junctions
Physiology
Invertebrates
Neurons
Tumors
Schizophrenia
Cytoplasm
Animals
Homeostasis
Genes
Adenosine Triphosphate
Maintenance
Genome
Inflammation

Keywords

  • Calcium wave
  • Cell-cell communication
  • Connexin
  • Gap junctions
  • Hemichannel
  • Innexin
  • Pannexin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Pannexins and gap junction protein diversity. / Shestopalov, Valery I; Panchin, Y.

In: Cellular and Molecular Life Sciences, Vol. 65, No. 3, 01.02.2008, p. 376-394.

Research output: Contribution to journalArticle

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