Pannexin: To gap or not to gap, is that a question?

Gerhard Dahl, Silviu Locovei

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.

Original languageEnglish
Pages (from-to)409-419
Number of pages11
JournalIUBMB Life
Volume58
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Connexins
Gap Junctions
Invertebrates
Ion Channels
Vertebrates
Adenosine Triphosphate

Keywords

  • ATP release
  • Calcium wave
  • Erythrocyte
  • Gap junction
  • Innexin
  • Pannexin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Pannexin : To gap or not to gap, is that a question? / Dahl, Gerhard; Locovei, Silviu.

In: IUBMB Life, Vol. 58, No. 7, 01.07.2006, p. 409-419.

Research output: Contribution to journalArticle

Dahl, Gerhard ; Locovei, Silviu. / Pannexin : To gap or not to gap, is that a question?. In: IUBMB Life. 2006 ; Vol. 58, No. 7. pp. 409-419.
@article{07d130656f8f4ca0b9cd7900caa5214e,
title = "Pannexin: To gap or not to gap, is that a question?",
abstract = "Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.",
keywords = "ATP release, Calcium wave, Erythrocyte, Gap junction, Innexin, Pannexin",
author = "Gerhard Dahl and Silviu Locovei",
year = "2006",
month = "7",
day = "1",
doi = "10.1080/15216540600794526",
language = "English",
volume = "58",
pages = "409--419",
journal = "IUBMB Life",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Pannexin

T2 - To gap or not to gap, is that a question?

AU - Dahl, Gerhard

AU - Locovei, Silviu

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.

AB - Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.

KW - ATP release

KW - Calcium wave

KW - Erythrocyte

KW - Gap junction

KW - Innexin

KW - Pannexin

UR - http://www.scopus.com/inward/record.url?scp=33745712366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745712366&partnerID=8YFLogxK

U2 - 10.1080/15216540600794526

DO - 10.1080/15216540600794526

M3 - Article

C2 - 16801216

AN - SCOPUS:33745712366

VL - 58

SP - 409

EP - 419

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 7

ER -