Pannexin: To gap or not to gap, is that a question?

Gerhard Dahl, Silviu Locovei

Research output: Contribution to journalReview article

134 Scopus citations

Abstract

Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional membrane channels. Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role.

Original languageEnglish (US)
Pages (from-to)409-419
Number of pages11
JournalIUBMB life
Volume58
Issue number7
DOIs
StatePublished - Jul 1 2006

Keywords

  • ATP release
  • Calcium wave
  • Erythrocyte
  • Gap junction
  • Innexin
  • Pannexin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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