Abstract
Intercellular calcium wave propagation initiated by mechanical stress is a phenomenon found in nearly all cell types. The waves utilize two pathways: transfer of InsP3 directly from cell to cell through gap junction channels and release of ATP onto extracellular purinergic receptors. The conduit for ATP has remained elusive and both a vesicular and a channel mediated release have been considered. Here, we describe the properties of single pannexin 1 channels. They have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive. Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress.
| Original language | English |
|---|---|
| Pages (from-to) | 65-68 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 572 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Aug 13 2004 |
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Keywords
- ATP
- Calcium wave
- Mechanoasensitivity
- Pannexin
- Single channel
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Pannexin membrane channels are mechanosensitive conduits for ATP. / Bao, Li; Locovei, Silviu; Dahl, Gerhard.
In: FEBS Letters, Vol. 572, No. 1-3, 13.08.2004, p. 65-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pannexin membrane channels are mechanosensitive conduits for ATP
AU - Bao, Li
AU - Locovei, Silviu
AU - Dahl, Gerhard
PY - 2004/8/13
Y1 - 2004/8/13
N2 - Intercellular calcium wave propagation initiated by mechanical stress is a phenomenon found in nearly all cell types. The waves utilize two pathways: transfer of InsP3 directly from cell to cell through gap junction channels and release of ATP onto extracellular purinergic receptors. The conduit for ATP has remained elusive and both a vesicular and a channel mediated release have been considered. Here, we describe the properties of single pannexin 1 channels. They have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive. Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress.
AB - Intercellular calcium wave propagation initiated by mechanical stress is a phenomenon found in nearly all cell types. The waves utilize two pathways: transfer of InsP3 directly from cell to cell through gap junction channels and release of ATP onto extracellular purinergic receptors. The conduit for ATP has remained elusive and both a vesicular and a channel mediated release have been considered. Here, we describe the properties of single pannexin 1 channels. They have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive. Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress.
KW - ATP
KW - Calcium wave
KW - Mechanoasensitivity
KW - Pannexin
KW - Single channel
UR - http://www.scopus.com/inward/record.url?scp=4143127920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4143127920&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2004.07.009
DO - 10.1016/j.febslet.2004.07.009
M3 - Article
C2 - 15304325
AN - SCOPUS:4143127920
VL - 572
SP - 65
EP - 68
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1-3
ER -