Pancuronium attenuates associated hemodynamic and transcutaneous oxygen tension changes during nursery procedures.

H. S. Bada, T. M. Burnette, Kristopher Arheart, N. Shull, R. Mirro, S. B. Korones

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Intermittent increases in blood pressure (BP) associated with motor activity have been implicated in the pathogenesis of intraventricular hemorrhage in premature infants. Inhibition of motor activity by pancuronium administration has also been shown to stabilize cerebral blood flow velocity (CBFV) and BP patterns. The purpose of this study was to determine whether administration of pancuronium to ill premature infants would attenuate changes in BP and transcutaneous oxygen tension (TcPO2) and the variability of CBFV pattern associated with common nursery procedures. Fourteen premature infants in the study were given a single dose of pancuronium bromide at a dose of 0.1 mg/kg intravenously. BP and TcPO2 changes were monitored during nursery procedures, that is, during radial artery blood gas sampling and a head ultrasonographic/Doppler procedure, before and during pancuronium therapy. During arterial blood gas sampling, mean percent increase in BP was significantly greater (32% +/- 21%) before pancuronium administration compared with 21% +/- 13% during pancuronium use (p < 0.05). Mean percent changes in TcPO2 were -30% +/- 21% and 5.8% +/- 7.2% before and during pancuronium use, respectively (p < 0.05). Similar significant changes in BP and TcPO2 were observed with a head ultrasonographic/Doppler procedure. Coefficients of variation of systolic and mean CBFV also decreased significantly during pancuronium therapy. We observed short-term benefits with pancuronium use on vascular dynamics and oxygenation during nursery procedures. Further studies are needed to evaluate the use of pancuronium in preterm babies supported by mechanical ventilation during the first few days of life for possible prevention of intraventricular hemorrhage, the pathophysiologic mechanism of which may be related to hemodynamic and biochemical derangement.

Original languageEnglish
Pages (from-to)119-123; quiz 124
JournalJournal of perinatology : official journal of the California Perinatal Association
Volume15
Issue number2
StatePublished - Mar 1 1995
Externally publishedYes

Fingerprint

Pancuronium
Nurseries
Hemodynamics
Oxygen
Cerebrovascular Circulation
Blood Pressure
Blood Flow Velocity
Premature Infants
Motor Activity
Gases
Head
Hemorrhage
Radial Artery
Artificial Respiration
Blood Vessels

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pancuronium attenuates associated hemodynamic and transcutaneous oxygen tension changes during nursery procedures. / Bada, H. S.; Burnette, T. M.; Arheart, Kristopher; Shull, N.; Mirro, R.; Korones, S. B.

In: Journal of perinatology : official journal of the California Perinatal Association, Vol. 15, No. 2, 01.03.1995, p. 119-123; quiz 124.

Research output: Contribution to journalArticle

Bada, H. S. ; Burnette, T. M. ; Arheart, Kristopher ; Shull, N. ; Mirro, R. ; Korones, S. B. / Pancuronium attenuates associated hemodynamic and transcutaneous oxygen tension changes during nursery procedures. In: Journal of perinatology : official journal of the California Perinatal Association. 1995 ; Vol. 15, No. 2. pp. 119-123; quiz 124.
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