Pancreaticoduodenectomy for nonperiampullary primary tumors

Lawrence E. Harrison, Nipun Merchant, Alfred M. Cohen, Murray F. Brennan

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


INTRODUCTION: This review was performed to evaluate the outcome of patients undergoing pancreaticoduodenectomy (PD) for isolated metastatic or locally advanced nonperiampullary tumors at a single institution over a 13- year period. METHODS: Between 1983 and 1996, patients undergoing PD for metastatic or locally advanced nonperiampullary malignancies were identified. Medical records were reviewed and outcome factors and survival data analyzed. RESULTS: Eighteen patients were identified. The primary tumor histopathology included colon (n = 7), gastric (n = 4), renal cell (n = 3), lung (n = 2), bladder (n = 1), and melanoma (n = 1). The median length of hospital stay was 15 days (6 to 48) with one perioperative death (5.5%). The median tumor size was 5.5 cm (0.8 to 11.5), and 7 patients had positive peripancreatic lymph nodes. The median survival was 40 months, with a 5-year survival of 35%. CONCLUSIONS: Pancreaticoduodenectomy for nonperiampullary malignancy is infrequently indicated. However, in the absence of widely metastatic disease, PD should be considered for locally advanced tumors or isolated metastatic malignancy.

Original languageEnglish (US)
Pages (from-to)393-395
Number of pages3
JournalAmerican journal of surgery
Issue number4
StatePublished - Oct 1997
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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