Abstract
Adult pancreatic regeneration is one of the most contentious topics in modern biology. The long-held view that the islets of Langerhans can be replenished throughout adult life through the reactivation of ductal progenitor cells has been replaced over the past decade by the now prevailing notion that regeneration does not involve progenitors and occurs only through the duplication of pre-existing mature cells. Here we dissect the limitations of lineage tracing (LT) to draw categorical conclusions about pancreatic regeneration, especially in view of emerging evidence that traditional lineages are less homogeneous and cell fates more dynamic than previously thought. This new evidence further suggests that the two competing hypotheses about regeneration are not mutually exclusive.
| Original language | English (US) |
|---|---|
| Journal | Trends in Endocrinology and Metabolism |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- dedifferentiation
- ductal cells
- human pancreatic progenitor cells
- islet regeneration
- type 1 diabetes
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Pancreatic Progenitors : There and Back Again. / Dominguez-Bendala, Juan; Qadir, Mirza Muhammad Fahd; Pastori, Ricardo.
In: Trends in Endocrinology and Metabolism, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pancreatic Progenitors
T2 - There and Back Again
AU - Dominguez-Bendala, Juan
AU - Qadir, Mirza Muhammad Fahd
AU - Pastori, Ricardo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Adult pancreatic regeneration is one of the most contentious topics in modern biology. The long-held view that the islets of Langerhans can be replenished throughout adult life through the reactivation of ductal progenitor cells has been replaced over the past decade by the now prevailing notion that regeneration does not involve progenitors and occurs only through the duplication of pre-existing mature cells. Here we dissect the limitations of lineage tracing (LT) to draw categorical conclusions about pancreatic regeneration, especially in view of emerging evidence that traditional lineages are less homogeneous and cell fates more dynamic than previously thought. This new evidence further suggests that the two competing hypotheses about regeneration are not mutually exclusive.
AB - Adult pancreatic regeneration is one of the most contentious topics in modern biology. The long-held view that the islets of Langerhans can be replenished throughout adult life through the reactivation of ductal progenitor cells has been replaced over the past decade by the now prevailing notion that regeneration does not involve progenitors and occurs only through the duplication of pre-existing mature cells. Here we dissect the limitations of lineage tracing (LT) to draw categorical conclusions about pancreatic regeneration, especially in view of emerging evidence that traditional lineages are less homogeneous and cell fates more dynamic than previously thought. This new evidence further suggests that the two competing hypotheses about regeneration are not mutually exclusive.
KW - dedifferentiation
KW - ductal cells
KW - human pancreatic progenitor cells
KW - islet regeneration
KW - type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85057285396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057285396&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2018.10.002
DO - 10.1016/j.tem.2018.10.002
M3 - Article
C2 - 30502039
AN - SCOPUS:85057285396
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
ER -