Pancreatic islet transplantation for treating diabetes

Shinichi Matsumoto, Hirofumi Noguchi, Yukihide Yonekawa, Teru Okitsu, Yasuhiro Iwanaga, Xiaoling Liu, Hideo Nagata, Naoya Kobayashi, Camillo Ricordi

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Pancreatic islet transplantation is one of the options for treating diabetes and has been shown to improve the quality of life of severe diabetic patients. Since the Edmonton protocol was announced, islet transplantation have advanced considerably, including islet after kidney transplantation, utilisation of non-heart-beating donors, single-donor islet transplantation and living-donor islet transplantation. These advances were based on revised immunosuppression protocols, improved pancreas procurement and islet isolation methods, and enhanced islet engraftment. Further improvements are necessary to make islet transplantation a routine clinical treatment. To synergise efforts towards a cure for type 1 diabetes, a Diabetes Research Institute (DRI) Federation is currently being established to include leading diabetes research centres worldwide, including DRIs in Miami, Edmonton and Kyoto among others.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalExpert Opinion on Biological Therapy
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2006

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Keywords

  • Diabetes Research Institute Federation
  • Islet transplantation
  • Kyoto Islet Isolation Method
  • Living donor islet
  • Non-heart-beating donor
  • Transplantation
  • Type 1 diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Matsumoto, S., Noguchi, H., Yonekawa, Y., Okitsu, T., Iwanaga, Y., Liu, X., Nagata, H., Kobayashi, N., & Ricordi, C. (2006). Pancreatic islet transplantation for treating diabetes. Expert Opinion on Biological Therapy, 6(1), 23-37. https://doi.org/10.1517/14712598.6.1.23