Pancreatic Islet Regeneration. The Developmental and Stem Cell Biology Approach.

Giacomo Lanzoni, Camillo Ricordi, Luca Inverardi, Juan Domínguez-Bendala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The quest for therapies that can normalize blood glucose control and provide independence from exogenous insulin could impact the life of millions of patients with type 1 diabetes (T1D) and a significant subset of patients with type 2 diabetes (T2D) with a functional deficiency in insulin production. Islet transplantation could be considered the first clinically successful cell therapy for T1D, but its widespread application is still hampered by the need for immunosuppression and the scarcity of organs available for processing and transplantation. The existence of these roadblocks has fostered the development of alternative approaches aimed at identifying high-yield sources of insulin-producing cells. Here we will discuss the state of the art in regenerative therapies for pancreatic islets, from stem cells to reprogramming. An outlook of the pancreatic development blueprint will help us in understanding key steps of stem cell differentiation, guiding us in the design of clinically translatable strategies. Major hurdles remain to be overcome for these approaches to find their way to the clinic: of these, we will specifically emphasize yield, safety, and immunological challenges.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages609-625
Number of pages17
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014

Keywords

  • β-cell differentiation
  • Diabetes
  • Insulin
  • Islet development
  • Pancreas
  • Pancreatic β cell
  • Reprogramming
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Lanzoni, G., Ricordi, C., Inverardi, L., & Domínguez-Bendala, J. (2014). Pancreatic Islet Regeneration. The Developmental and Stem Cell Biology Approach. In Regenerative Medicine Applications in Organ Transplantation (pp. 609-625). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00042-2