Pancreatic duct ligation in the therapy of chronic pancreatitis

Duane Hutson, Joe Levi, Alan Livingstone, R. Zeppa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalAmerican Surgeon
Volume45
Issue number7
StatePublished - Dec 1 1979

Fingerprint

Pancreatic Ducts
Chronic Pancreatitis
Glucose Tolerance Test
Ligation
Islets of Langerhans
Dogs
Insulin
Pancreatectomy
Acinar Cells
Therapeutics
Pancreatitis
Atrophy
Pancreas

ASJC Scopus subject areas

  • Surgery

Cite this

Pancreatic duct ligation in the therapy of chronic pancreatitis. / Hutson, Duane; Levi, Joe; Livingstone, Alan; Zeppa, R.

In: American Surgeon, Vol. 45, No. 7, 01.12.1979, p. 449-452.

Research output: Contribution to journalArticle

Hutson, D, Levi, J, Livingstone, A & Zeppa, R 1979, 'Pancreatic duct ligation in the therapy of chronic pancreatitis', American Surgeon, vol. 45, no. 7, pp. 449-452.
Hutson, Duane ; Levi, Joe ; Livingstone, Alan ; Zeppa, R. / Pancreatic duct ligation in the therapy of chronic pancreatitis. In: American Surgeon. 1979 ; Vol. 45, No. 7. pp. 449-452.
@article{1021ab5c792a44669403170c65d2f1af,
title = "Pancreatic duct ligation in the therapy of chronic pancreatitis",
abstract = "Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal.",
author = "Duane Hutson and Joe Levi and Alan Livingstone and R. Zeppa",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "45",
pages = "449--452",
journal = "The American surgeon",
issn = "0003-1348",
publisher = "Southeastern Surgical Congress",
number = "7",

}

TY - JOUR

T1 - Pancreatic duct ligation in the therapy of chronic pancreatitis

AU - Hutson, Duane

AU - Levi, Joe

AU - Livingstone, Alan

AU - Zeppa, R.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal.

AB - Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal.

UR - http://www.scopus.com/inward/record.url?scp=0018582971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018582971&partnerID=8YFLogxK

M3 - Article

C2 - 380423

AN - SCOPUS:0018582971

VL - 45

SP - 449

EP - 452

JO - The American surgeon

JF - The American surgeon

SN - 0003-1348

IS - 7

ER -