Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair

Nagaraj Nagathihalli, Erika T. Brown

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic cancer is an aggressive solid malignancy with poor response to therapy and the subsequent dismal survival rate has remained a hallmark of this disease. There is evidence to indicate that pancreatic cancer is initiated and propagated by cancer stem cell (CSC)s. The CSC population is defined by its tumor initiating capacity and has been shown to be invasive or metastatic. Loss of genome stability is a hallmark of cancer with DNA repair enzymes aiding in maintenance of stability. The potential to assess the risk of cancer development lies in careful determination of one's capacity in nurturing genome stability. DNA repair genes are over expressed in CSCs and both pancreatic CSCs and invasive cells in turn provide greater DNA damage response and repair mechanisms. Pancreatic tumor-initiating cells as well as invasive cells have a large number of genes related to DNA repair. RAD51, the key player in the recombinational repair of damaged DNA might act as a critical mediator of efficient DNA repair mechanisms of CSCs. We update here the current research results regarding CSCs in pancreatic cancer progression, metastasis and discuss the DNA repair mechanism in pancreatic CSCs.

Original languageEnglish (US)
Title of host publicationDNA Repair of Cancer Stem Cells
PublisherSpringer Netherlands
Pages141-155
Number of pages15
ISBN (Print)9789400745902, 9400745893, 9789400745896
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Keywords

  • Cancer stem cells
  • DNA repair
  • EMT
  • Metastasis
  • Pancreatic cancer
  • RAD51

ASJC Scopus subject areas

  • Medicine(all)

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