Pancreas transplantation in the setting of multivisceral transplantation

Mahmoud Morsi, Gaetano Ciancio, Javier Gonzalez, Ahmed Farag, Rodrigo Vianna

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pancreas transplant as a part of multivisceral or multiorgan transplantation has always been approached with caution because of graft pancreatitis, rejection, or technical complications. The multivisceral transplantation is a complicated process, starting from the recipient, the donor selection, the indications, the contraindications, and the postoperative management. Intestinal transplant recipients generally require more profound immunosuppression than patients receiving other solid organs because of the higher immunogenicity of the intestine. Unlike the early years of intestinal transplantation, when technical challenges and vascular events were likely to cause graft loss and patient mortality, the current most common causes of allograft dysfunction are infection and graft rejection. Unlike the early years of intestinal transplantation, when technical challenges and vascular events were likely to cause graft loss and patient mortality, the current most common causes of allograft dysfunction are infection and graft rejection.

Original languageEnglish (US)
Title of host publicationTransplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publicationVolume 1
PublisherElsevier
Pages179-193
Number of pages15
ISBN (Electronic)9780128148334
ISBN (Print)9780128148341
DOIs
StatePublished - Jan 1 2019

Keywords

  • Bowel transplant
  • Graft vs host disease
  • Immunosuppression
  • Intestinal failure
  • Multivisceral transplant
  • Pancreas transplant
  • Pancreatitis
  • Rejection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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