Abstract
The pancreas transplant as a part of multivisceral or multiorgan transplantation has always been approached with caution because of graft pancreatitis, rejection, or technical complications. The multivisceral transplantation is a complicated process, starting from the recipient, the donor selection, the indications, the contraindications, and the postoperative management. Intestinal transplant recipients generally require more profound immunosuppression than patients receiving other solid organs because of the higher immunogenicity of the intestine. Unlike the early years of intestinal transplantation, when technical challenges and vascular events were likely to cause graft loss and patient mortality, the current most common causes of allograft dysfunction are infection and graft rejection. Unlike the early years of intestinal transplantation, when technical challenges and vascular events were likely to cause graft loss and patient mortality, the current most common causes of allograft dysfunction are infection and graft rejection.
Original language | English (US) |
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Title of host publication | Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas |
Subtitle of host publication | Volume 1 |
Publisher | Elsevier |
Pages | 179-193 |
Number of pages | 15 |
ISBN (Electronic) | 9780128148334 |
ISBN (Print) | 9780128148341 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- Bowel transplant
- Graft vs host disease
- Immunosuppression
- Intestinal failure
- Multivisceral transplant
- Pancreas transplant
- Pancreatitis
- Rejection
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)