Painful physical symptoms in depression: A clinical challenge

Thomas N. Wise, David A Fishbain, Vicenzio Holder-Perkins

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Painful physical symptoms are common elements within mood disorders and provide a therapeutic challenge when such patients attribute their pain to causes other than the mood disorder. These somatic presentations may lead to under-diagnosis and inappropriate treatment of patients with mood disorders. Antidepressant agents that inhibit both serotonin and norepinephrine reuptake effectively remit mood disorders, thereby providing relief of painful physical symptoms often associated with these disorders. They may also provide analgesia for neuropathic pain, such as that caused by diabetic neuropathy, which are associated with mood disorders. Newer generation dual acting antidepressants such as duloxetine and venlafaxine offer a well-tolerated and safe alternative to tricyclics. Concurrent with medication and management, the physician must educate the patient about the nature of both depressed mood and painful physical states that are augmented by and inherent in the depressive disorders. This mini review addresses the problems inherent to the treatment of painful physical symptoms in depression.

Original languageEnglish
JournalPain Medicine
Volume8
Issue numberSUPPL. 2
DOIs
StatePublished - Sep 1 2007

Fingerprint

Mood Disorders
Depression
Antidepressive Agents
Diabetic Neuropathies
Neuralgia
Depressive Disorder
Analgesia
Serotonin
Norepinephrine
Therapeutics
Physicians
Pain

Keywords

  • Affective Disorders
  • Depression
  • Pain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Painful physical symptoms in depression : A clinical challenge. / Wise, Thomas N.; Fishbain, David A; Holder-Perkins, Vicenzio.

In: Pain Medicine, Vol. 8, No. SUPPL. 2, 01.09.2007.

Research output: Contribution to journalArticle

Wise, Thomas N. ; Fishbain, David A ; Holder-Perkins, Vicenzio. / Painful physical symptoms in depression : A clinical challenge. In: Pain Medicine. 2007 ; Vol. 8, No. SUPPL. 2.
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