Pain and genetics

Claudia R. Fernandez Robles, Meredith Degnan, Keith A Candiotti

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Pain management is one of the most important fields in the practice of anesthesiology. The concept that genes involved in the absorption, metabolism, and receptor affinity of analgesics are critical to a drug's efficacy is becoming widely accepted. A review of pharmacogenomics and how it affects the response to analgesics, mainly opioids, is presented in this article. RECENT FINDINGS: As the field of pharmacogenomics expands, more and more candidate genes are being evaluated. Genes related to the μ-opioid receptor, ATP-binding cassette subfamily B, catechol-O-methyltransferase, and cytochrome 2D6 currently show promise in helping predict the gene phenotype. Recent studies have also focused on the interleukin-1 receptor antagonist and the melanocortin-1 receptor, further adding to the picture. SUMMARY: Through increased knowledge in the area of pharmacogenomics, it is hoped that that treatment of pain will move into the realm of personalized medicine. This should result in greater treatment success and a reduction of significant side-effects.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalCurrent Opinion in Anaesthesiology
Volume25
Issue number4
DOIs
StatePublished - Aug 1 2012

Fingerprint

Pharmacogenetics
Pain
Genes
Receptor, Melanocortin, Type 1
Catechol O-Methyltransferase
Precision Medicine
Anesthesiology
Interleukin-1 Receptors
Opioid Receptors
Pain Management
Cytochromes
Opioid Analgesics
Analgesics
Adenosine Triphosphate
Phenotype
Therapeutics
Pharmaceutical Preparations

Keywords

  • genetics
  • opioids
  • pain
  • pharmacogenomics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Pain and genetics. / Fernandez Robles, Claudia R.; Degnan, Meredith; Candiotti, Keith A.

In: Current Opinion in Anaesthesiology, Vol. 25, No. 4, 01.08.2012, p. 444-449.

Research output: Contribution to journalArticle

Fernandez Robles, Claudia R. ; Degnan, Meredith ; Candiotti, Keith A. / Pain and genetics. In: Current Opinion in Anaesthesiology. 2012 ; Vol. 25, No. 4. pp. 444-449.
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