Pain

Jun Chen, Ji Sheng Han, Zhi Qi Zhao, Feng Wei, Jen Chuen Hsieh, Lan Bao, Andrew C.N. Chen, Yi Dai, Bi Fa Fan, Jian Guo Gu, Shuanglin Hao, San Jue Hu, Yong Hua Ji, Yong Jie Li, Yun Qing Li, Qing Lin, Xian Guo Liu, Yan Qing Liu, Yan Lu, Fei LuoChao Ma, Yun Hai Qiu, Zhi Ren Rao, Lin Shi, Bai Chuang Shyu, Xue Jun Song, Jing Shi Tang, Yuan Xiang Tao, You Wan, Jia Shuang Wang, Ke Wei Wang, Yun Wang, Guang Yin Xu, Tian Le Xu, Hao Jun You, Long Chuan Yu, Sheng Yuan Yu, Da Ying Zhang, De Ren Zhang, Jun Ming Zhang, Xu Zhang, Yu Qiu Zhang, Min Zhuo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be differentiated into acute pain and chronic pain according to its duration, with 3 months as a tentative defining point in humans. Acute pain is good for protection from dangerous health issues and relatively easy to control. Chronic pain, on the other hand, is absolutely annoying and notoriously difficult to manage. Chronic pain can be induced by various causes, such as inflammatory or metabolic disorders of the peripheral tissue, musculoskeletal strain, peripheral or central nervous lesion and diseases, etc., yet their common mechanism is hypersensitivity of the pain transmission and perception systems, which may result in a structural disorganization. The suffering from chronic pain has been a powerful driving force for pain research both in academic institutions and in the industry. This chapter focuses on the system of noxious signal transmission, from the ion channel and nociceptor to the psychological reaction, from the ascending pain perception pathways to the descending pain modulatory pathways, being facilitatory or inhibitory. Principles of biomedical interventions on acute and chronic pain are also outlined.

Original languageEnglish (US)
Title of host publicationNeuroscience in the 21st Century
Subtitle of host publicationFrom Basic to Clinical, Second Edition
PublisherSpringer New York
Pages1091-1149
Number of pages59
ISBN (Electronic)9781493934744
ISBN (Print)9781493934737
DOIs
StatePublished - Jan 1 2016

Fingerprint

Chronic Pain
pain
Acute Pain
Pain
Pain Perception
Psychological Stress
Nociceptors
Ion Channels
Industry
Hypersensitivity
Psychology
Health
Research
educational institutions
metabolic diseases
ion channels
hypersensitivity
lesions (animal)
industry

Keywords

  • Acupuncture modulation
  • Acupuncture modulation of pain
  • Amygdala
  • Axonal reflex
  • Behavioral pain hypersensitivity
  • Bell-magendie law
  • Biochemical neuroimaging
  • Brain matrix
  • Brain mechanisms
  • Cerebellum
  • Cortical and subcortical processing
  • Disinhibition
  • Drug modulation
  • Functional neuroimaging
  • Gabapentin
  • Gatecontrol theory of pain
  • Gene therapy and stem cell treatment
  • Glial cells
  • Hyperalgesia
  • Hypothalamus
  • Insula
  • K2P
  • Nerve injury-induced neural plasticity
  • Neurochemical markers
  • Neurogenic inflammation
  • Neuromodulation
  • Neuromodulation
  • Neuropathic
  • Nociception
  • Nociceptive flexion reflex (NFR)
  • Nociceptive specific (NS) neurons
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • P2X3 receptor
  • P2Y receptors
  • Pain
  • Pain
  • Pain
  • Pain
  • Pain
  • Pain
  • Pain matrix
  • Peptidergic population of c nociceptors
  • Periaqueductal gray (PAG)
  • Peripheral mechanisms
  • Peripheral nociceptors
  • Placebo modulation
  • Placebo modulation
  • Primary afferent depolarization (PAD)
  • Pro-inflammatory cytokines
  • Psychological modulation
  • Rostral ventromedial medulla (RVM)
  • Specificity theory
  • Spinal cord dorsal horn
  • Spinal pain sensory neurons
  • Structural neuroimaging
  • Tanezumab
  • Thalamic pain syndrome
  • Transient receptor potential vanilloid receptor 1 (TRPV1)
  • Tripartite synaptic model
  • Vanilloid receptor-like protein 1 (VRL1)
  • Ventrolateral orbital cortex (VLO)
  • Voltage-gated potassium channels (VGPCs)
  • Voxel-based morphometry
  • Windup phenomenon

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

Cite this

Chen, J., Han, J. S., Zhao, Z. Q., Wei, F., Hsieh, J. C., Bao, L., ... Zhuo, M. (2016). Pain. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition (pp. 1091-1149). Springer New York. https://doi.org/10.1007/978-1-4939-3474-4_32

Pain. / Chen, Jun; Han, Ji Sheng; Zhao, Zhi Qi; Wei, Feng; Hsieh, Jen Chuen; Bao, Lan; Chen, Andrew C.N.; Dai, Yi; Fan, Bi Fa; Gu, Jian Guo; Hao, Shuanglin; Hu, San Jue; Ji, Yong Hua; Li, Yong Jie; Li, Yun Qing; Lin, Qing; Liu, Xian Guo; Liu, Yan Qing; Lu, Yan; Luo, Fei; Ma, Chao; Qiu, Yun Hai; Rao, Zhi Ren; Shi, Lin; Shyu, Bai Chuang; Song, Xue Jun; Tang, Jing Shi; Tao, Yuan Xiang; Wan, You; Wang, Jia Shuang; Wang, Ke Wei; Wang, Yun; Xu, Guang Yin; Xu, Tian Le; You, Hao Jun; Yu, Long Chuan; Yu, Sheng Yuan; Zhang, Da Ying; Zhang, De Ren; Zhang, Jun Ming; Zhang, Xu; Zhang, Yu Qiu; Zhuo, Min.

Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. p. 1091-1149.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chen, J, Han, JS, Zhao, ZQ, Wei, F, Hsieh, JC, Bao, L, Chen, ACN, Dai, Y, Fan, BF, Gu, JG, Hao, S, Hu, SJ, Ji, YH, Li, YJ, Li, YQ, Lin, Q, Liu, XG, Liu, YQ, Lu, Y, Luo, F, Ma, C, Qiu, YH, Rao, ZR, Shi, L, Shyu, BC, Song, XJ, Tang, JS, Tao, YX, Wan, Y, Wang, JS, Wang, KW, Wang, Y, Xu, GY, Xu, TL, You, HJ, Yu, LC, Yu, SY, Zhang, DY, Zhang, DR, Zhang, JM, Zhang, X, Zhang, YQ & Zhuo, M 2016, Pain. in Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, pp. 1091-1149. https://doi.org/10.1007/978-1-4939-3474-4_32
Chen J, Han JS, Zhao ZQ, Wei F, Hsieh JC, Bao L et al. Pain. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York. 2016. p. 1091-1149 https://doi.org/10.1007/978-1-4939-3474-4_32
Chen, Jun ; Han, Ji Sheng ; Zhao, Zhi Qi ; Wei, Feng ; Hsieh, Jen Chuen ; Bao, Lan ; Chen, Andrew C.N. ; Dai, Yi ; Fan, Bi Fa ; Gu, Jian Guo ; Hao, Shuanglin ; Hu, San Jue ; Ji, Yong Hua ; Li, Yong Jie ; Li, Yun Qing ; Lin, Qing ; Liu, Xian Guo ; Liu, Yan Qing ; Lu, Yan ; Luo, Fei ; Ma, Chao ; Qiu, Yun Hai ; Rao, Zhi Ren ; Shi, Lin ; Shyu, Bai Chuang ; Song, Xue Jun ; Tang, Jing Shi ; Tao, Yuan Xiang ; Wan, You ; Wang, Jia Shuang ; Wang, Ke Wei ; Wang, Yun ; Xu, Guang Yin ; Xu, Tian Le ; You, Hao Jun ; Yu, Long Chuan ; Yu, Sheng Yuan ; Zhang, Da Ying ; Zhang, De Ren ; Zhang, Jun Ming ; Zhang, Xu ; Zhang, Yu Qiu ; Zhuo, Min. / Pain. Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. pp. 1091-1149
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AU - Dai, Yi

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AU - Gu, Jian Guo

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AU - Hu, San Jue

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AU - Li, Yong Jie

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AU - Wang, Ke Wei

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AU - Xu, Guang Yin

AU - Xu, Tian Le

AU - You, Hao Jun

AU - Yu, Long Chuan

AU - Yu, Sheng Yuan

AU - Zhang, Da Ying

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N2 - Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be differentiated into acute pain and chronic pain according to its duration, with 3 months as a tentative defining point in humans. Acute pain is good for protection from dangerous health issues and relatively easy to control. Chronic pain, on the other hand, is absolutely annoying and notoriously difficult to manage. Chronic pain can be induced by various causes, such as inflammatory or metabolic disorders of the peripheral tissue, musculoskeletal strain, peripheral or central nervous lesion and diseases, etc., yet their common mechanism is hypersensitivity of the pain transmission and perception systems, which may result in a structural disorganization. The suffering from chronic pain has been a powerful driving force for pain research both in academic institutions and in the industry. This chapter focuses on the system of noxious signal transmission, from the ion channel and nociceptor to the psychological reaction, from the ascending pain perception pathways to the descending pain modulatory pathways, being facilitatory or inhibitory. Principles of biomedical interventions on acute and chronic pain are also outlined.

AB - Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be differentiated into acute pain and chronic pain according to its duration, with 3 months as a tentative defining point in humans. Acute pain is good for protection from dangerous health issues and relatively easy to control. Chronic pain, on the other hand, is absolutely annoying and notoriously difficult to manage. Chronic pain can be induced by various causes, such as inflammatory or metabolic disorders of the peripheral tissue, musculoskeletal strain, peripheral or central nervous lesion and diseases, etc., yet their common mechanism is hypersensitivity of the pain transmission and perception systems, which may result in a structural disorganization. The suffering from chronic pain has been a powerful driving force for pain research both in academic institutions and in the industry. This chapter focuses on the system of noxious signal transmission, from the ion channel and nociceptor to the psychological reaction, from the ascending pain perception pathways to the descending pain modulatory pathways, being facilitatory or inhibitory. Principles of biomedical interventions on acute and chronic pain are also outlined.

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KW - Acupuncture modulation of pain

KW - Amygdala

KW - Axonal reflex

KW - Behavioral pain hypersensitivity

KW - Bell-magendie law

KW - Biochemical neuroimaging

KW - Brain matrix

KW - Brain mechanisms

KW - Cerebellum

KW - Cortical and subcortical processing

KW - Disinhibition

KW - Drug modulation

KW - Functional neuroimaging

KW - Gabapentin

KW - Gatecontrol theory of pain

KW - Gene therapy and stem cell treatment

KW - Glial cells

KW - Hyperalgesia

KW - Hypothalamus

KW - Insula

KW - K2P

KW - Nerve injury-induced neural plasticity

KW - Neurochemical markers

KW - Neurogenic inflammation

KW - Neuromodulation

KW - Neuromodulation

KW - Neuropathic

KW - Nociception

KW - Nociceptive flexion reflex (NFR)

KW - Nociceptive specific (NS) neurons

KW - Nonsteroidal anti-inflammatory drugs (NSAIDs)

KW - P2X3 receptor

KW - P2Y receptors

KW - Pain

KW - Pain

KW - Pain

KW - Pain

KW - Pain

KW - Pain

KW - Pain matrix

KW - Peptidergic population of c nociceptors

KW - Periaqueductal gray (PAG)

KW - Peripheral mechanisms

KW - Peripheral nociceptors

KW - Placebo modulation

KW - Placebo modulation

KW - Primary afferent depolarization (PAD)

KW - Pro-inflammatory cytokines

KW - Psychological modulation

KW - Rostral ventromedial medulla (RVM)

KW - Specificity theory

KW - Spinal cord dorsal horn

KW - Spinal pain sensory neurons

KW - Structural neuroimaging

KW - Tanezumab

KW - Thalamic pain syndrome

KW - Transient receptor potential vanilloid receptor 1 (TRPV1)

KW - Tripartite synaptic model

KW - Vanilloid receptor-like protein 1 (VRL1)

KW - Ventrolateral orbital cortex (VLO)

KW - Voltage-gated potassium channels (VGPCs)

KW - Voxel-based morphometry

KW - Windup phenomenon

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