Paget'S disease of the skin. A unifying concept of histogenesis

Mehrdad Nadji, Azorides R. Morales, Robert E. Girtanner, Jocelyne Ziegels‐Weissman, Neal S. Penneys

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Utilizing the peroxidase antiperoxidase technique we explored the presence and the distribution of carcinoembryonic antigen (CEA) in seven cases of mammary and sixteen of extramammary Paget's disease of skin. In every case positive immunostaining was observed in all the Paget's cells and the underlying tumor (where one was present), whereas intervening keratinocytes and melanocytes did not stain. CEA was also present in the cells and secretions of normal eccrine and apocrine glands. Our observations confirm that Paget's cells are of glandular origin.

Original languageEnglish (US)
Pages (from-to)2203-2206
Number of pages4
Issue number10
StatePublished - Nov 15 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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