Paget's disease of the skin. A unifying concept of histogenesis

Mehrdad Nadji, Azorides R Morales, R. E. Morales

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Utilizing the peroxidase antiperoxidase technique we explored the presence and the distribution of carcinoembryonic antigen (CEA) in seven cases of mammary and sixteen of extramammary Paget's disease of skin. In every case positive immunostaining was observed in all the Paget's cells and the underlying tumor (where one was present), whereas intervening keratinocytes and melanocytes did not stain. CEA was also present in the cells and secretions of normal eccrine and apocrine glands. Our observations confirm that Paget's cells are of glandular origin.

Original languageEnglish
Pages (from-to)2203-2206
Number of pages4
JournalCancer
Volume50
Issue number10
StatePublished - Dec 1 1982

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Skin Diseases
Carcinoembryonic Antigen
Extramammary Paget's Disease
Apocrine Glands
Eccrine Glands
Melanocytes
Keratinocytes
Peroxidase
Breast
Coloring Agents
Skin
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nadji, M., Morales, A. R., & Morales, R. E. (1982). Paget's disease of the skin. A unifying concept of histogenesis. Cancer, 50(10), 2203-2206.

Paget's disease of the skin. A unifying concept of histogenesis. / Nadji, Mehrdad; Morales, Azorides R; Morales, R. E.

In: Cancer, Vol. 50, No. 10, 01.12.1982, p. 2203-2206.

Research output: Contribution to journalArticle

Nadji, M, Morales, AR & Morales, RE 1982, 'Paget's disease of the skin. A unifying concept of histogenesis', Cancer, vol. 50, no. 10, pp. 2203-2206.
Nadji M, Morales AR, Morales RE. Paget's disease of the skin. A unifying concept of histogenesis. Cancer. 1982 Dec 1;50(10):2203-2206.
Nadji, Mehrdad ; Morales, Azorides R ; Morales, R. E. / Paget's disease of the skin. A unifying concept of histogenesis. In: Cancer. 1982 ; Vol. 50, No. 10. pp. 2203-2206.
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