TY - JOUR
T1 - Paget's disease of the nipple
AU - Sandoval-Leon, Ana C.
AU - Drews-Elger, Katherine
AU - Gomez-Fernandez, Carmen R.
AU - Yepes, Monica M.
AU - Lippman, Marc E.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Paget's disease of the breast is a disorder of the nipple-areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget's disease. The Epidermotropic, which is the most accepted theory, suggests that Paget's cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget's disease. This article provides an overview of Paget's disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.
AB - Paget's disease of the breast is a disorder of the nipple-areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget's disease. The Epidermotropic, which is the most accepted theory, suggests that Paget's cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget's disease. This article provides an overview of Paget's disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.
KW - Breast cancer
KW - Her2
KW - Immunohistochemistry
KW - Paget's disease
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U2 - 10.1007/s10549-013-2661-4
DO - 10.1007/s10549-013-2661-4
M3 - Review article
C2 - 23929251
AN - SCOPUS:84881080787
VL - 141
SP - 1
EP - 12
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -