Paget's disease of the nipple

Ana C. Sandoval-Leon, Katherine Drews-Elger, Carmen R. Gomez-Fernandez, Monica M. Yepes, Marc E. Lippman

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Paget's disease of the breast is a disorder of the nipple-areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget's disease. The Epidermotropic, which is the most accepted theory, suggests that Paget's cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget's disease. This article provides an overview of Paget's disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBreast cancer research and treatment
Volume141
Issue number1
DOIs
StatePublished - Aug 1 2013

Keywords

  • Breast cancer
  • Her2
  • Immunohistochemistry
  • Paget's disease

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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