Abstract
Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.
| Original language | English (US) |
|---|---|
| Title of host publication | Primer on the Rheumatic Diseases: Thirteenth Edition |
| Publisher | Springer New York |
| Pages | 573-575 |
| Number of pages | 3 |
| ISBN (Print) | 9780387356648 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Paget's disease of bone. / Altman, Roy D.
Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, 2008. p. 573-575.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Paget's disease of bone
AU - Altman, Roy D
PY - 2008
Y1 - 2008
N2 - Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.
AB - Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.
UR - http://www.scopus.com/inward/record.url?scp=84892213403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892213403&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-68566-3_34
DO - 10.1007/978-0-387-68566-3_34
M3 - Chapter
AN - SCOPUS:84892213403
SN - 9780387356648
SP - 573
EP - 575
BT - Primer on the Rheumatic Diseases: Thirteenth Edition
PB - Springer New York
ER -