Paget's disease of bone

Roy D Altman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.

Original languageEnglish (US)
Title of host publicationPrimer on the Rheumatic Diseases: Thirteenth Edition
PublisherSpringer New York
Pages573-575
Number of pages3
ISBN (Print)9780387356648
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Osteitis Deformans
Skeleton
Bone and Bones
Osteoclasts
Bone Resorption
Osteoblasts
Fibrosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Altman, R. D. (2008). Paget's disease of bone. In Primer on the Rheumatic Diseases: Thirteenth Edition (pp. 573-575). Springer New York. https://doi.org/10.1007/978-0-387-68566-3_34

Paget's disease of bone. / Altman, Roy D.

Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, 2008. p. 573-575.

Research output: Chapter in Book/Report/Conference proceedingChapter

Altman, RD 2008, Paget's disease of bone. in Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, pp. 573-575. https://doi.org/10.1007/978-0-387-68566-3_34
Altman RD. Paget's disease of bone. In Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York. 2008. p. 573-575 https://doi.org/10.1007/978-0-387-68566-3_34
Altman, Roy D. / Paget's disease of bone. Primer on the Rheumatic Diseases: Thirteenth Edition. Springer New York, 2008. pp. 573-575
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