Paget's disease of bone

Roy D. Altman

doi:10.1007/978-0-387-68566-3_34

Paget's disease of bone

Roy D. Altman

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.

Original language	English (US)
Title of host publication	Primer on the Rheumatic Diseases
Subtitle of host publication	Thirteenth Edition
Publisher	Springer New York
Pages	573-575
Number of pages	3
ISBN (Print)	9780387356648
DOIs	https://doi.org/10.1007/978-0-387-68566-3_34
State	Published - Dec 1 2008

ASJC Scopus subject areas

Medicine(all)

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AB - Paget's disease is a chronic disorder of the adult skeleton characterized by increased resorption and deposition of bone resulting in replacement of the normal matrix with a softened and enlarged bone. Initially, there is active resorption by large and increased numbers of osteoclasts containing multiple nuclei, followed by deposition of bone by numerous osteoblasts which most often results in a weakened disorganized bony structure that is interspersed with areas of fibrosis. Although localized to isolated areas of the skeleton, there may be widespread bony distribution.

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Paget's disease of bone

Abstract

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