Pacritinib to inhibit JAK/STAT signaling in refractory metastatic colon and rectal cancer

Thomas Regenbogen, Ling Chen, Kathryn Trinkaus, Andrea Wang-Gillam, Benjamin R. Tan, Manik Amin, Katrina S. Pedersen, Haeseong Park, Rama Suresh, Kian Huat Lim, Emily Ratchford, Amberly Brown, Albert Lockhart

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4 Scopus citations

Abstract

Background: Treatment options for patients with refractory colorectal cancer are limited and typically provide a chance of only modest benefit. The goal of this study was to evaluate the benefit of inhibiting the JAK/STAT inflammatory pathway with single agent pacritinib in patients with metastatic refractory colorectal adenocarcinoma. Methods: A single arm institutional trial was initiated and enrolled patients with metastatic colorectal cancer refractory to at least two standard lines of treatment. Pacritinib 400 mg daily was administered orally continuously in 28 day cycles. Results: The trial was discontinued prior to reaching the planned accrual due to an FDA hold on pacritinib and a lack of treatment benefit. Eleven patients were enrolled and seven were evaluated for response. Median baseline C-reactive protein level was 12.1 (2.1-147) mg/L. One patient had stable disease at eight weeks by RECIST criteria and six progressed. There were no grade 4 or 5 adverse events while patients were on study. The grade 2 and lower AE events experienced were consistent with prior pacritinib trials. Conclusions: In seven evaluable patients there were no objective responses. The trial was discontinued prior to completing planned accrual based on a low likelihood that the progression free survival goal of 4 months would be met.

Original languageEnglish (US)
Pages (from-to)985-989
Number of pages5
JournalJournal of Gastrointestinal Oncology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2017

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Keywords

  • Colorectal cancer
  • Pacritinib
  • Refractory

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Regenbogen, T., Chen, L., Trinkaus, K., Wang-Gillam, A., Tan, B. R., Amin, M., Pedersen, K. S., Park, H., Suresh, R., Lim, K. H., Ratchford, E., Brown, A., & Lockhart, A. (2017). Pacritinib to inhibit JAK/STAT signaling in refractory metastatic colon and rectal cancer. Journal of Gastrointestinal Oncology, 8(6), 985-989. https://doi.org/10.21037/jgo.2017.08.16